CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytidine deaminase 
Protein Synonyms/Alias
 Cytidine aminohydrolase; CDA 
Gene Name
 cdd 
Gene Synonyms/Alias
 b2143; JW2131 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
168LPDAFGPKDLEIKTLacetylation[1]
208RSHMPYSKSPSGVALacetylation[1]
265QRAVLAEKADAPLIQacetylation[1]
281DATSATLKALGCHSIacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. 
Sequence Annotation
 DOMAIN 56 139 CMP/dCMP deaminase zinc-binding.
 REGION 89 91 Substrate binding.
 ACT_SITE 104 104 Proton donor.
 METAL 102 102 Zinc; catalytic.
 METAL 129 129 Zinc; catalytic.
 METAL 132 132 Zinc; catalytic.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 294 AA 
Protein Sequence
MHPRFQTAFA QLADNLQSAL EPILADKYFP ALLTGEQVSS LKSATGLDED ALAFALLPLA 60
AACARTPLSN FNVGAIARGV SGTWYFGANM EFIGATMQQT VHAEQSAISH AWLSGEKALA 120
AITVNYTPCG HCRQFMNELN SGLDLRIHLP GREAHALRDY LPDAFGPKDL EIKTLLMDEQ 180
DHGYALTGDA LSQAAIAAAN RSHMPYSKSP SGVALECKDG RIFSGSYAEN AAFNPTLPPL 240
QGALILLNLK GYDYPDIQRA VLAEKADAPL IQWDATSATL KALGCHSIDR VLLA 294 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0004126; F:cytidine deaminase activity; IDA:EcoCyc.
 GO:0047844; F:deoxycytidine deaminase activity; IDA:EcoCyc.
 GO:0001884; F:pyrimidine nucleoside binding; IDA:EcoliWiki.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0006217; P:deoxycytidine catabolic process; IDA:EcoCyc.
 GO:0015949; P:nucleobase-containing small molecule interconversion; IDA:EcoliWiki. 
Interpro
 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR002125; CMP_dCMP_Zn-bd.
 IPR013171; Cyd/dCyd_deaminase_Zn-bd.
 IPR006263; Cyt_deam_dimer.
 IPR016193; Cytidine_deaminase-like.
 IPR020797; Cytidine_deaminase_bacteria. 
Pfam
 PF00383; dCMP_cyt_deam_1
 PF08211; dCMP_cyt_deam_2 
SMART
  
PROSITE
 PS00903; CYT_DCMP_DEAMINASES 
PRINTS