| Tag | Content |
|---|
| CPLM ID | CPLM-017246 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CST complex subunit STN1 |
Protein Synonyms/Alias | Alpha-accessory factor of 44 kDa; AAF-44; AAF44; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog |
Gene Name | Obfc1 |
Gene Synonyms/Alias | Stn1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 39 | AFAKLYIKDILEMKE | ubiquitination | [1] | | 182 | ARMLELPKLYQKVYD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. |
Sequence Annotation | DNA_BIND 64 165 OB. |
Keyword | 3D-structure; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Reference proteome; Telomere. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 378 AA |
Protein Sequence | MPQPCLLMEC ESSPREEEIP PLFWGLDPVF LAFAKLYIKD ILEMKESQQV PGTYFYNGHP 60
IRRVDIMGAV ISVKERETFY SYGVDDATGV INCVCWKKLS NAESSSDPAI LSTARELSMT 120
SQLKKLQETI EQKTRIGIGD IIRVRGSVRM FREEREICAN IYYKVDDPVW NMQIARMLEL 180
PKLYQKVYDQ PFRNPALQEE EALNNKDNLD LAGLTSLLSE KIKEFLQEKK MQSFYQQELE 240
TVESLQSLAS RPVTHSTGSD QVELKDSGTS GVAQRVFKNA LQLLQEKGLV FQRDSGSDKL 300
YYVTTKDKDL QQKIYHIIKE DCQKPNHMEK GCHLLHILNC VHLNLRWDLS KAVLQRVLEL 360
LEDQSDIVST ADHYYAAF 378 |
Gene Ontology | GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara. GO:0005730; C:nucleolus; IEA:Compara. GO:0070188; C:Stn1-Ten1 complex; IDA:UniProtKB. GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB. GO:0045740; P:positive regulation of DNA replication; IDA:UniProtKB. GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |