UniProt Accession

 PURA_PLAF7; Q8IDF6 

Genbank Protein ID

 AL844509 

Genbank Nucleotide ID

 CAD52666.1 

Protein Name

 Adenylosuccinate synthetase 

Protein Synonyms/Alias

 AMPSase; AdSS; IMP--aspartate ligase 

Gene Name

 Adss 

Gene Synonyms/Alias

 PF13_0287 

Created Date

 July 27, 2013 

Organism

 Plasmodium falciparum (isolate 3D7) 

NCBI Taxa ID

 36329 

Lysine Modification

Position	Peptide	Type	References
130	IDSIQETKKLKEGKQ	acetylation	[1]
131	DSIQETKKLKEGKQI	acetylation	[1]
133	IQETKKLKEGKQIGT	acetylation	[1]
136	TKKLKEGKQIGTTKR	acetylation	[1]

Reference

 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 

Functional Description

 Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). 

Sequence Annotation

 NP_BIND 25 31 GTP (By similarity).
 NP_BIND 53 55 GTP (By similarity).
 NP_BIND 339 341 GTP (By similarity).
 NP_BIND 425 427 GTP (By similarity).
 REGION 26 29 IMP binding (By similarity).
 REGION 51 54 IMP binding (By similarity).
 REGION 307 313 Substrate binding (By similarity).
 ACT_SITE 26 26 Proton acceptor (By similarity).
 ACT_SITE 54 54 Proton donor (By similarity).
 METAL 26 26 Magnesium (By similarity).
 METAL 53 53 Magnesium; via carbonyl oxygen (By
 BINDING 62 62 GTP (By similarity).
 BINDING 141 141 IMP (By similarity).
 BINDING 155 155 IMP; shared with dimeric partner (By
 BINDING 232 232 IMP (By similarity).
 BINDING 247 247 IMP (By similarity).
 BINDING 307 307 GTP (By similarity).
 BINDING 311 311 IMP (By similarity).
 BINDING 313 313 GTP (By similarity).  

Keyword

 Complete proteome; Cytoplasm; GTP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Purine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 442 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004019; F:adenylosuccinate synthase activity; IEA:HAMAP.
 GO:0005525; F:GTP binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0044208; P:'de novo' AMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006167; P:AMP biosynthetic process; ISS:GeneDB_Pfalciparum. 

Interpro

 IPR018220; Adenylosuccinate_synthase_AS.
 IPR001114; Adenylosuccinate_synthetase.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00709; Adenylsucc_synt 

SMART

 SM00788; Adenylsucc_synt 

PROSITE

 PS01266; ADENYLOSUCCIN_SYN_1
 PS00513; ADENYLOSUCCIN_SYN_2 

PRINTS