CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008405
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinate-semialdehyde dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase 
Gene Name
 ALDH5A1 
Gene Synonyms/Alias
 SSADH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
126ERSSLLRKWYNLMIQacetylation[1]
135YNLMIQNKDDLARIIacetylation[2]
279CTDPLVSKISFTGSTubiquitination[3]
358GIHDAFVKAFAEAMKacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). 
Sequence Annotation
 NP_BIND 228 231 NAD.
 NP_BIND 284 289 NAD.
 ACT_SITE 306 306 Proton acceptor (By similarity).
 ACT_SITE 340 340 Nucleophile (By similarity).
 BINDING 213 213 NAD.
 BINDING 213 213 Substrate.
 BINDING 334 334 Substrate.
 BINDING 498 498 Substrate.
 MOD_RES 126 126 N6-acetyllysine.
 DISULFID 340 342 In inhibited form.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR LAGLSAALLR 60
TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKER 120
SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIH 180
TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL 240
AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV 300
KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF 360
AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF 420
EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR 480
VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL 535 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0042803; F:protein homodimerization activity; IC:UniProtKB.
 GO:0004777; F:succinate-semialdehyde dehydrogenase (NAD+) activity; IDA:UniProtKB.
 GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
 GO:0006083; P:acetate metabolic process; ISS:UniProtKB.
 GO:0007417; P:central nervous system development; IMP:UniProtKB.
 GO:0006681; P:galactosylceramide metabolic process; ISS:UniProtKB.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IDA:UniProtKB.
 GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
 GO:0006678; P:glucosylceramide metabolic process; IEA:Compara.
 GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.
 GO:0006541; P:glutamine metabolic process; ISS:UniProtKB.
 GO:0006749; P:glutathione metabolic process; ISS:UniProtKB.
 GO:0006650; P:glycerophospholipid metabolic process; ISS:UniProtKB.
 GO:0042135; P:neurotransmitter catabolic process; ISS:UniProtKB.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; ISS:UniProtKB.
 GO:0046459; P:short-chain fatty acid metabolic process; ISS:UniProtKB.
 GO:0006105; P:succinate metabolic process; ISS:UniProtKB. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010102; Succ_semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS