| Tag | Content |
|---|
| CPLM ID | CPLM-018611 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin repeat and SOCS box protein 8 |
Protein Synonyms/Alias | ASB-8 |
Gene Name | Asb8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 232 | IMPREVTKDQQLCEK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
Sequence Annotation | REPEAT 52 81 ANK 1.
REPEAT 85 113 ANK 2.
REPEAT 117 146 ANK 3.
REPEAT 150 179 ANK 4.
DOMAIN 235 288 SOCS box. |
Keyword | ANK repeat; Complete proteome; Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 288 AA |
Protein Sequence | MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA 60
CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAERDEAC VEVLLEYGAN PNALDGNRDT 120
PLHWAAFKNN AECVRALLES GASVNALDYN NDTPLSWAAM KGNLESVSIL LDYGAEVRVI 180
NLKGQTPISR LVALLVRGLG TEKEDSCFEL LHRAVGQFEL RKNGIMPREV TKDQQLCEKL 240
TVLCSAPGTL KTLARYAVRR SLGLQYLPDA VKGLPLPVSL KDYLLLLE 288 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |