UniProt Accession

 EHF_HUMAN; Q9NZC4; D3DR08; D3DR10; E9PSB2; Q9H509; Q9UKF9; Q9Y5V4; Q9Y5V5 

Genbank Protein ID

 AF170583; AF124438; AF124439; AF212848; AF203977; AY882601; AK310867; AC087783; AL157952; AL157952; CH471064; CH471064; CH471064; CH471064; CH471064; BC038995 

Genbank Nucleotide ID

 AAF06998.1; AAD30990.1; AAD30991.1; AAF61670.1; AAG35644.1; AAW80658.1; CAC12700.1; CAC12701.1; EAW68162.1; EAW68163.1; EAW68164.1; EAW68165.1; EAW68166.1; AAH38995.1 

Protein Name

 ETS homologous factor 

Protein Synonyms/Alias

 hEHF; ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; ESE-3 

Gene Name

 EHF 

Gene Synonyms/Alias

 ESE3; ESE3B; ESEJ 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
164	TVDLLDSKTFCRAQI	acetylation	[1]
188	VAESPDMKKEQDPPA	acetylation	[1]
196	KEQDPPAKCHTKKHN	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. 

Sequence Annotation

 DOMAIN 29 115 PNT.
 DNA_BIND 207 289 ETS.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:UniProtKB.
 GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB.
 GO:0007275; P:multicellular organismal development; TAS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF02198; SAM_PNT 

SMART

 SM00413; ETS
 SM00251; SAM_PNT 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 

PRINTS

 PR00454; ETSDOMAIN.