UniProt Accession

 E9QKD9_MOUSE; E9QKD9 

Genbank Protein ID

 AC090122; AC090123 

Genbank Nucleotide ID

  

Protein Name

 General transcription factor IIH subunit 1 

Protein Synonyms/Alias

  

Gene Name

 Gtf2h1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
245	DRLNTGSKDLFAECA	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 553 AA 

Protein Sequence

Gene Ontology

 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR005607; BSD.
 IPR011993; PH_like_dom.
 IPR027079; Tfb1/p62.
 IPR013876; TFIIH_BTF_p62_N. 

Pfam

 PF03909; BSD
 PF08567; TFIIH_BTF_p62_N 

SMART

 SM00751; BSD 

PROSITE

 PS50858; BSD 

PRINTS