CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042513
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitogen-activated protein kinase kinase kinase 6 
Protein Synonyms/Alias
  
Gene Name
 MAP3K6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
264NKVLLPAKLEVRGTDubiquitination[1]
497HIVHRDIKGDNVLINubiquitination[1]
634DPFLQPGKRSRSPSSubiquitination[1]
723SLLHQESKRRAMLAAubiquitination[1]
748ENLHQEQKQEQGARLubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 798 AA 
Protein Sequence
XMNLLLSYRD VQDYSAIIEL VETLQALPTC DVAEQHNVCF HYTFALNRRN RPGDRAKALS 60
VLLPLVQLEG SVAPDLYCMC GRIYKDMFFS SGFQDAGHRE QAYHWYRKAF DVEPSLHSGI 120
NAAVLLIAAG QHFEDSKELR LIGMKLGCLL ARKGCVEKMQ YYWDVGFYLG AQILANDPTQ 180
VVLAAEQLYK LNAPIWYLVS VMETFLLYQH FRPTPEPPGG PPRRAHFWLH FLLQSCQPFK 240
TACAQGDQCL VLVLEMNKVL LPAKLEVRGT DPVSTVTLSL LEPETQDIPS SWTFPVASIC 300
GVSASKRDER CCFLYALPPA QDVQLCFPSV GHCQWFCGLI QAWVTNPDST APAEEAEGAG 360
EMLEFDYEYT ETGERLVLGK GTYGVVYAGR DRHTRVRIAI KEIPERDSRF SQPLHEEIAL 420
HRRLRHKNIV RYLGSASQGG YLKIFMEEVP GGSLSSLLRS VWGPLKDNES TISFYTRQIL 480
QGLGYLHDNH IVHRDIKGDN VLINTFSGLL KISDFGTSKR LAGITPCTET FTGTLQYMAP 540
EIIDQGPRGY GKAADIWSLG CTVIEMATGR PPFHELGSPQ AAMFQVGMYK VHPPMPSSLS 600
AEAQAFLLRT FEPDPRLRAS AQTLLGDPFL QPGKRSRSPS SPRHAPRPSD APSASPTPSA 660
NSTTQSQTFP CPQAPSQHPP SPPKRCLSYG GTSQLRVPEE PAAEEPASPE ESSGLSLLHQ 720
ESKRRAMLAA VLEQELPALA ENLHQEQKQE QGARLGRNHV EELLRCLGAH IHTPNRRQLA 780
QELRALQGWM NGEDKGSF 798 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR025136; DUF4071.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF13281; DUF4071
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS