UniProt Accession

 ITPA_MOUSE; Q9D892; Q8R0Q8 

Genbank Protein ID

 AK008279; BC026508 

Genbank Nucleotide ID

 BAB25571.1; AAH26508.1 

Protein Name

 Inosine triphosphate pyrophosphatase 

Protein Synonyms/Alias

 ITPase; Inosine triphosphatase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; NTPase 

Gene Name

 Itpa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	AASLVGKKIVFVTGN	acetylation	[1]
56	PDEISIQKCREAARQ	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. 

Sequence Annotation

 REGION 14 19 Substrate binding (By similarity).
 REGION 72 73 Substrate binding (By similarity).
 REGION 149 152 Substrate binding (By similarity).
 REGION 177 178 Substrate binding (By similarity).
 METAL 44 44 Magnesium or manganese (By similarity).
 METAL 72 72 Magnesium or manganese (By similarity).
 BINDING 56 56 Substrate (By similarity).
 BINDING 172 172 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0035870; F:dITP diphosphatase activity; IMP:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0051276; P:chromosome organization; IMP:MGI.
 GO:0009204; P:deoxyribonucleoside triphosphate catabolic process; IEA:HAMAP.
 GO:0006193; P:ITP catabolic process; IMP:MGI. 

Interpro

 IPR002637; Ham1p-like.
 IPR027502; ITPase. 

Pfam

 PF01725; Ham1p_like 

SMART

  

PROSITE

  

PRINTS