CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011277
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clathrin coat assembly protein AP180 
Protein Synonyms/Alias
 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180 
Gene Name
 Snap91 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
134YSRYLNEKAFSYRQMubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats. 
Sequence Annotation
 DOMAIN 14 145 ENTH.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 312 312 Phosphothreonine (By similarity).
 MOD_RES 313 313 Phosphoserine.
 MOD_RES 316 316 Phosphoserine (By similarity).
 MOD_RES 600 600 Phosphoserine.
 MOD_RES 640 640 Phosphoserine.
 MOD_RES 646 646 Phosphoserine.
 CARBOHYD 310 310 O-linked (GlcNAc).  
Keyword
 Alternative splicing; Cell membrane; Coated pit; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 915 AA 
Protein Sequence
MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN ETNVNIPQMA 60
DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR NTLFNLSNFL DKSGSHGYDM 120
STFIRRYSRY LNEKAFSYRQ MAFDFARVKK GADGVMRTMV PEKLLKSMPI LQGQIDALLE 180
FDVHPNELTN GVINAAFMLL FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF 240
LTRMTRVSEF LKVADEVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNNEGSGAPS 300
PLSKSSPATT VTSPNSTPAK TIDTSPPVDI FATASAAAPV SSAKPSSDLL DLQPDFSGAR 360
AGAAAPVPPP TGGATAWGDL LGEDSLAALS SVPSEAPISD PFAPEPSPPT TTTEPASASA 420
SATTAVTAAT TEVDLFGDAF AASPGEAPAA SEGATAPATP APVAAALDAC SGNDPFAPSE 480
GSAEAAPELD LFAMKPPETS APVVTPTAST APPVPATAPS PAPTAVAATA ATTTAAAAAT 540
TTATTSAAAA TTAAAPPALD IFGDLFDSAP EVAAASKPDV APSIDLFGTD AFSSPPRGAS 600
PVPESSLTAD LLSGSGFHCA EDDRHVPLFF TAVDAFAAPS PASTASPAKA ESSGVIDLFG 660
DAFGSSASET QPAPQAVSSS SASADLLAGF GGSFMAPSTT PVTPAQNNLL QPNFEAAFGT 720
TPSTSSSSSF DPSGDLLMPT MAPSGQPAPV SMVPPSPAMS ASKGLGSDLD SSLASLVGNL 780
GISGTTSKKG DLQWNAGEKK LTGGANWQPK VTPATWSAGV PPQGTVPPTS SVPPGAGAPS 840
VGQPGAGYGM PPAGTGMTMM PQQPVMFAQP MMRPPFGAAA VPGTQLSPSP TPATQSPKKP 900
PAKDPLADLN IKDFL 915 
Gene Ontology
 GO:0030118; C:clathrin coat; IEA:InterPro.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0014069; C:postsynaptic density; IDA:BHF-UCL.
 GO:0045211; C:postsynaptic membrane; IDA:BHF-UCL.
 GO:0042734; C:presynaptic membrane; IDA:BHF-UCL.
 GO:0008021; C:synaptic vesicle; IDA:BHF-UCL.
 GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
 GO:0007409; P:axonogenesis; IMP:BHF-UCL.
 GO:0048268; P:clathrin coat assembly; IEA:InterPro.
 GO:0007163; P:establishment or maintenance of cell polarity; IMP:BHF-UCL.
 GO:0030100; P:regulation of endocytosis; IMP:BHF-UCL.
 GO:0051223; P:regulation of protein transport; IMP:BHF-UCL. 
Interpro
 IPR011417; ANTH_dom.
 IPR014712; Clathrin_Pinositid-bd_GAT-like.
 IPR008942; ENTH_VHS.
 IPR013809; Epsin-like_N. 
Pfam
 PF07651; ANTH 
SMART
 SM00273; ENTH 
PROSITE
 PS50942; ENTH 
PRINTS