CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023515
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CASP8-associated protein 2 
Protein Synonyms/Alias
 FLICE-associated huge protein 
Gene Name
 Casp8ap2 
Gene Synonyms/Alias
 Flash 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1323WELKTPEKQLLESLKacetylation[1]
1536PSTSPGLKHGVVAEEacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF-alpha-induced activation of NF- kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. 
Sequence Annotation
 REGION 1688 1962 NCOA2-binding (By similarity).
 MOTIF 1716 1720 SUMO interaction motif 1 (SIM); mediates
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 20 20 Phosphoserine (By similarity).
 CROSSLNK 92 92 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Activator; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Isopeptide bond; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1962 AA 
Protein Sequence
MAADDDNGDG TGLFDVCPAS PLKNNDEGSL DIYAGLDSAV SDSTARSCVS FRNCLDLYEE 60
ILTEEGTAKE ATYNDLQIEY GKCQQQMKDL MKRFKEIQTQ NLNLKNENQS LKKNISALIK 120
TARVEINRKD EEINHLHQRL SEFPHFRNNH KTARTKDSQS TSPHLDDCSK TDHGVKSDVQ 180
KDVHPNTAQP NLEKEGKSHS EAQNPLHLST GVEKHCANNV WSRSPYQVGE GNSNEDNRRG 240
RSGTRHSQCS RGTDRTQKDL HSSCNDSEPR DKEANSRLQG HPEKHGNSEA RTESKISESK 300
SSTGMGYKSE RSASSWEKET SRERPHTRVE SQHDKNLEKQ NERLQNMHRK ELPSQDKTER 360
KVDVKFKPAG EEQGHRGRVD RALPPHPKND VKHYGFNKYH PEERRGREDC KRDRGMNSHG 420
FQDRRCSSFL SSNRNSKYPH SKEVSVAHQW ENTPFKAERH RTEDRRKRER ENKEESRHVK 480
SDKKSPPEHL QRTHKDTKKS TADGKRQTEP KHGKGAVSNS ELSKGTDSKE GATKVESGPN 540
EAKGKDLKLS FMEKLNLTLS PAKKQPACQD NPHQITGVPE PSGTCDSRSL ETTGTVACLP 600
SGSEHNREET KSELPEPKEA LLATSQLRIS IPENKMKEEK RLLFKSVENT VPCELLACGT 660
EISLPAPVEI EQARCLLGSV EVEETCGGAR TAASVVMHVL PEHASEDASQ ELDTKRHDGI 720
NACAISEGVK TKVILSPKAA AASESHLAPL VEEPSISLVN CSGDNNPKLE PSLEERPIVE 780
TKSCPLESCL PKETFVPSPQ KTELIDHKIE TGESNSVYQD DDNSVLSIDF NNLRPIPDPI 840
SPLNSPVRPV CKVVSMESSC AIPLYDSSHK DEFPSNSTLS TFKSQSDLNK ENEKPVPKFD 900
KCSEADSCKH LSLDELEEGE IRSDDEESVA QKRLEKSARP RVSAEVQPGK SSPGSRRSTV 960
HVHKDNGRTA VKLPRDRLTW SKRSSESRPS NTERKSKTMS ISSLEKILPL ILVPSSLWEV 1020
MHMLRLLGKH VRKNYMKFKI KFSLTQFHRI IESAILSFTS LVKCLDLSKI CKSVSTLQKS 1080
LCEVIESNLK QVKKNGIVDR LFEQQQTDMK KKLWKFVDEQ LDYLFEKLKK ILLKFCDSVN 1140
FENENSEGKL GKKYKERTQH SNCQKKKMDN KEIRREKVLK SENTVNFKSS LGCEKSEEKH 1200
QDQNKTNASI VKHDVKRTFS TCSDNTKNAE CKEQFLEKSC PSTPRPGKDE GHTEEEAQAA 1260
QHASAKSERS FEILTEQQAS SLTFNLVSDA QMGEIFKSLL QGSDLLDTSG TEKAEWELKT 1320
PEKQLLESLK CESAPACATE ELVSEGASLC PKVISDDNWS LLSSEKGPSL SSGLSLPVHP 1380
DVLDENCMFE VSSNTALGKD NVYSSEKSKP CISSILLEDL AVSLTVPSPL KSDGHLSFLK 1440
PEVLSTSTPE EVISAHFSED ALLEEEDASE QDIHLALESD NSSSKSSCSS WTSRSVASGF 1500
QYHPNLPMHA VIMEKSNDHF IVKIRRATPS TSPGLKHGVV AEESLTSLPR TGKEAGVATE 1560
KEPNLFQSTV LKPVKDLENT DKNIDKSKLT HEEQNSIVQT QVPDIYEFLK DASNKVVHCD 1620
QVVDDCFKLH QVWEPKVSEN LQELPSMEKI PHSLDNHLPD THIDLTKDSA TETKSLGELM 1680
EVTVLNVDHL ECSQTNLDQD AEITCSSLQP DTIDAFIDLT HDASSESKNE GSEPVLAVEG 1740
MGCQVICIDE DTNKEGKMGR ANSPLESIVE ETCIDLTSES PGSCEIKRHN LKSEPPSKLD 1800
CLELPETLGN GHKKRKNSPG VSHSSQKKQR KDIDLSSEKT QRLSPNSDRN GDAHRKQASK 1860
KREPAVNETS LSSEASPEVK GSTAVLAASP ASLSAKNVIK KKGEIIVSWT RNDDREILLE 1920
CQKRMPSLKT FTYLAVKLNK NPNQVSERFQ QLKKLFEKSK CR 1962 
Gene Ontology
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0016605; C:PML body; ISS:UniProtKB.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0032184; F:SUMO polymer binding; ISS:UniProtKB.
 GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
 GO:0036337; P:Fas signaling pathway; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009057; Homeodomain-like. 
Pfam
  
SMART
  
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