CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030432
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DOCK10.2 
Protein Synonyms/Alias
 Dedicator of cytokinesis protein 10 
Gene Name
 DOCK10.2 
Gene Synonyms/Alias
 DOCK10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
249VQNNRLRKYAFELKMubiquitination[1]
343TETEDTVKTTRNMERubiquitination[1, 2]
364DPDIDTLKLQKKDLLubiquitination[1]
378LEPESVIKPFEEKAAubiquitination[1]
483GLPEEWLKFPKQAVFubiquitination[1]
522SGAEPYIKNPDSNKYubiquitination[1]
828KHGGSDIKWVDGGKPacetylation[2, 3]
948SYIKFVFKTRACKERubiquitination[1]
1914LLKLYADKFGADNVKubiquitination[1]
1983PFTLSGKKHGGVAEQubiquitination[1]
2114DVNERLIKEDQLEYQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2180 AA 
Protein Sequence
MSFRGKVFKR EPSEFWKKRR TVRRVNQEEI HRFSSQEKPR LLEPLDYETV IEELEKTYRN 60
DPLQDLLFFP SDDFSAATVS WDIRTLYSTV PEDAEHKAEN LLVKEACKFY SSQWHVVNYK 120
YEQYSGDIRQ LPRAEYKPEK LPSHSFEIDH EDADKDEDTT SHSSSKGGGG AGGTGVFKSG 180
WLYKGNFNST VNNTVTVRSF KKRYFQLTQL PDNSYIMNFY KDEKISKEPK GCIFLDSCTG 240
VVQNNRLRKY AFELKMNDLT YFVLAAETES DMDEWIHTLN RILQISPEGP LQGRRSTELT 300
DLGLDSLDNS VTCECTPEET DSSENNLHAD FAKYLTETED TVKTTRNMER LNLFSLDPDI 360
DTLKLQKKDL LEPESVIKPF EEKAAKRIMI ICKALNSNLQ GCVTENENDP ITNIEPFFVS 420
VALYDLRDSR KISADFHVDL NHAAVRQMLL GASVALENGN IDTITPRQSE EPHIKGLPEE 480
WLKFPKQAVF SVSNPHSEIV LVAKIEKVLM GNIASGAEPY IKNPDSNKYA QKILKSNRQF 540
CSKLGKYRMP FAWAVRSVFK DNQGNVDRDS RFSPLFRQES SKISTEDLVK LVSDYRRADR 600
ISKMQTIPGS LDIAVDNVPL EHPNCVTSSF IPVKPFNMMA QTEPTVEVEE FVYDSTKYCR 660
PYRVYKNQIY IYPKHLKYDS QKCFNKARNI TVCIEFKNSD EESAKPLKCI YGKPGGPLFT 720
SAAYTAVLHH SQNPDFSDEV KIELPTQLHE KHHILFSFYH VTCDINAKAN AKKKEALETS 780
VGYAWLPLMK HDQIASQEYN IPIATSLPPN YLSFQDSASG KHGGSDIKWV DGGKPLFKVS 840
TFVVSTVNTQ DPHVNAFFQE CQKREKDMSQ SPTSNFIRSC KNLLNVEKIH AIMSFLPIIL 900
NQLFKVLVQN EEDEITTTVT RVLTDIVAKC HEEQLDHSVQ SYIKFVFKTR ACKERTVHEE 960
LAKNVTGLLK SNDSTTVKHV LKHSWFFFAI ILKSMAQHLI DTNKIQLPRP QRFPESYQNE 1020
LDNLVMVLSD HVIWKYKDAL EETRRANHSV ARFLKRCFTF MDRGYVFKMV NNYISMFSSG 1080
DLKTLCQYKF DFLQEVCQHE HFIPLCLPIR SANIPDPLTP SESTQELHAS DMPEYSVTNE 1140
FCRKHFLIGI LLREVGFALQ EDQDVRHLAL AVLKNLMAKH SFDDRYREPR KQAQIASLYM 1200
PLYGMLLDNM PRIYLKDLYP FTVNTSNQGS RDDLSTNGGF QSQTAIKHAN SVDTSFSKDV 1260
LNSIAAFSSI AISTVNHADS RASLASLDSN PSTNEKSSEK TDNCEKIPRP LSLIGSTLRF 1320
DKLDQAETRS LLMCFLHIMK TISYETLIAY WQRAPSPEVS DFFSILDVCL QNFRYLGKRN 1380
IIRKIAAAFK FVQSTQNNGT LKGSNPSCQT SGLLSQWMHS TSSHEGHKQH RSQTLPIIRG 1440
KNALSNPKLL QMLDNTMTSN SNEIDIVHHV DTEANIATEV CLTILDLLSL FTQTHQRQLQ 1500
QCDCQNSLMK RVFDTYMLFF QVNQSATALK HVFASLRLFV CKFPSAFFQG PADLCGSFCY 1560
EVLKCCNHRS RSTQTEASAL LYFFMRKNFE FNKQKSIVRS HLQLIKAVSQ LIADAGIGGS 1620
RFQHSLAITN NFANGDKQMK NSNFPAEVKD LTKRIRTVLM ATAQMKEHEK DPEMLVDLQY 1680
SLANSYASTP ELRRTWLESM AKIHARNGDL SEAAMCYIHI AALIAEYLKR KGYWKVEKIC 1740
TASLLSEDTH PCDSNSLLTT PSGGSMFSMG WPAFLSITPN IKEEGAMKED SGMQDTPYNE 1800
NILVEQLYMC VEFLWKSERY ELIADVNKPI IAVFEKQRDF KKLSDLYYDI HRSYLKVAEV 1860
VNSEKRLFGR YYRVAFYGQG FFEEEEGKEY IYKEPKLTGL SEISQRLLKL YADKFGADNV 1920
KIIQDSNKVN PKDLDPKYAY IQVTYVTPFF EEKEIEDRKT DFEMHHNINR FVFETPFTLS 1980
GKKHGGVAEQ CKRRTILTTS HLFPYVKKRI QVISQSSTEL NPIEVAIDEM SKKVSELNQL 2040
CTMEEVDMIR LQLKLQGSVS VKVNAGPMAY ARAFLEETNA KKYPDNQVKL LKEIFRQFAD 2100
ACGQALDVNE RLIKEDQLEY QEELRSHYKD MLSELSTVMN EQITGRDDLS KRGVDQTCTR 2160
VISKATPALP TVSISSSAEV 2180 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026796; DOCK_D.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2
 PS50003; PH_DOMAIN 
PRINTS