CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031887
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pleckstrin homology domain-containing family B member 2 
Protein Synonyms/Alias
  
Gene Name
 PLEKHB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MAFVKSGWLLRQubiquitination[1]
17LRQSTILKRWKKNWFubiquitination[2]
46TRQNIEDKVHMPMDCubiquitination[2, 3]
71DTQPPDGKSKDCMLQubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 309 AA 
Protein Sequence
MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ 60
ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT 120
DETSVVSSPP PYTAYAAPAP EELHSKGPKI HTTTSAKTQA VLPTRCFFPS ESPIRRSVQI 180
SVLLPAVNIR RRIKLTFPQP ARPRAPRSLC LWQTWFAGKR APSLPTAATA PALPSCPSPP 240
APSQALPPSL AGWRSPSSAP LPPEQALAPR SFQLSKHQAR PRPHRPGTPP VPAWPGVPPP 300
PPARPPALR 309 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS