UniProt Accession

 RNPA_ECOLI; P0A7Y8; P06277; Q2M816 

Genbank Protein ID

 M11056; X01861; L10328; U00096; AP009048 

Genbank Nucleotide ID

 AAA24567.1; CAA25983.1; AAA62055.1; AAC76727.1; BAE77590.1 

Protein Name

 Ribonuclease P protein component 

Protein Synonyms/Alias

 RNase P protein; RNaseP protein; Protein C5 

Gene Name

 rnpA 

Gene Synonyms/Alias

 b3704; JW3681 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
107	ALSEALEKLWRRHCR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 119 AA 

Protein Sequence

Gene Ontology

 GO:0004526; F:ribonuclease P activity; IDA:EcoCyc.
 GO:0000049; F:tRNA binding; IEA:InterPro.
 GO:0001682; P:tRNA 5'-leader removal; IDA:EcoliWiki. 

Interpro

 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
 IPR000100; RNase_P.
 IPR020539; RNase_P_CS. 

Pfam

 PF00825; Ribonuclease_P 

SMART

  

PROSITE

 PS00648; RIBONUCLEASE_P 

PRINTS