CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PDZ domain-containing RING finger protein 4 
Protein Synonyms/Alias
 Ligand of Numb protein X 4; SEMACAP3-like protein 
Gene Name
 PDZRN4 
Gene Synonyms/Alias
 LNX4; SEMCAP3L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
993NIIELSHKKMMKKRNacetylation[1]
994IIELSHKKMMKKRNKacetylation[1]
997LSHKKMMKKRNKKILacetylation[1]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
  
Sequence Annotation
 DOMAIN 224 314 PDZ 1.
 DOMAIN 402 486 PDZ 2.
 ZN_FING 18 56 RING-type; degenerate.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1036 AA 
Protein Sequence
MGFALERFAE AVDPALECKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR RCPLQCQPLA 60
PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH VEHCDFGPAR RLRSRGGCAS 120
GLGGGEVPAR GGCGPTPRAG RGGGARGGPP GGRWGRGRGP GPRVLAWRRR EKALLAQLWA 180
LQGEVQLTAR RYQEKFTQYM AHVRNFVGDL GGGHRRDGEH KPFTIVLERE NDTLGFNIIG 240
GRPNQNNQEG TSTEGIYVSK ILENGPADRA DGLEIHDKIM EVNGKDLSKA THEEAVEAFR 300
NAKEPIVVQV LRRTPLSRPA YGMASEVQLM NASTQTDITF EHIMALAKLR PPTPPVPDIC 360
PFLLSDSCHS LHPMEHEFYE DNEYISSLPA DADRTEDFEY EEVELCRVSS QEKLGLTVCY 420
RTDDEEDTGI YVSEVDPNSI AAKDGRIREG DRILQINGED VQNREEAVAL LSNDECKRIV 480
LLVARPEIQL DEGWLEDERN EFLEELNLEM LEEEHNEAMQ PTANEVEQPK KQEEEEGTTD 540
TATSSSNNHE KDSGVGRTDE SLRNDESSEQ ENAAEDPNST SLKSKRDLGQ SQDTLGSVEL 600
QYNESLVSGE YIDSDCIGNP DEDCERFRQL LELKCKIRNH GEYDLYYSSS TIECNQGEQE 660
GVEHELQLLN EELRNIELEC QNIMQAHRLQ KVTDQYGDIW TLHDGGFRNY NTSIDMQRGK 720
LDDIMEHPEK SDKDSSSAYN TAESCRSTPL TVDRSPDSSL PRVINLTNKK NLRSTMAATQ 780
SSSGQSSKES TSTKAKTTEQ GCSAESKEKV LEGSKLPDQE KAVSEHIPYL SPYHSSSYRY 840
ANIPAHARHY QSYMQLIQQK SAVEYAQSQL SLVSMCKESQ KCSEPKMEWK VKIRSDGTRY 900
ITKRPVRDRI LKERALKIKE ERSGMTTDDD TMSEMKMGRY WSKEERKQHL VRAKEQRRRR 960
EFMMRSRLEC LKESPQSGSE GKKEINIIEL SHKKMMKKRN KKILDNWMTI QELMTHGAKS 1020
PDGTRVHNAF LSVTTV 1036 
Gene Ontology
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001478; PDZ.
 IPR013323; SIAH-type.
 IPR008974; TRAF-like.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ
 SM00184; RING 
PROSITE
 PS50106; PDZ
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS