UniProt Accession

 B7ZNL3_MOUSE; B7ZNL3 

Genbank Protein ID

 AC166370; BC145307; CH466522 

Genbank Nucleotide ID

 AAI45308.1; EDL26146.1 

Protein Name

 Tpm1 protein 

Protein Synonyms/Alias

 Tropomyosin 1, alpha, isoform CRA_g; Tropomyosin alpha-1 chain 

Gene Name

 Tpm1 

Gene Synonyms/Alias

 mCG_1234 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	KKKMQMLKLDKENAL	acetylation	[1]
12	KKKMQMLKLDKENAL	ubiquitination	[2]
15	MQMLKLDKENALDRA	acetylation	[1, 3, 4]
15	MQMLKLDKENALDRA	ubiquitination	[2]
29	AEQAEADKKAAEDRS	ubiquitination	[2]
30	EQAEADKKAAEDRSK	ubiquitination	[2]
37	KAAEDRSKQLEEDIA	ubiquitination	[2]
128	DESERGMKVIESRAQ	ubiquitination	[2]
136	VIESRAQKDEEKMEI	acetylation	[1, 3]
136	VIESRAQKDEEKMEI	ubiquitination	[2]
140	RAQKDEEKMEIQEIQ	acetylation	[3]
140	RAQKDEEKMEIQEIQ	ubiquitination	[2]
149	EIQEIQLKEAKHIAE	acetylation	[3]
149	EIQEIQLKEAKHIAE	ubiquitination	[2]
152	EIQLKEAKHIAEDAD	acetylation	[3, 4]
152	EIQLKEAKHIAEDAD	ubiquitination	[2]
161	IAEDADRKYEEVARK	acetylation	[3]
161	IAEDADRKYEEVARK	ubiquitination	[2]
168	KYEEVARKLVIIESD	ubiquitination	[2]
189	RAELSEGKCAELEEE	ubiquitination	[2]
198	AELEEELKTVTNNLK	ubiquitination	[2]
205	KTVTNNLKSLEAQAE	acetylation	[3]
205	KTVTNNLKSLEAQAE	ubiquitination	[2]
213	SLEAQAEKYSQKEDK	acetylation	[1, 3]
213	SLEAQAEKYSQKEDK	ubiquitination	[2]
217	QAEKYSQKEDKYEEE	acetylation	[1, 3]
217	QAEKYSQKEDKYEEE	ubiquitination	[2]
220	KYSQKEDKYEEEIKV	acetylation	[1, 3]
220	KYSQKEDKYEEEIKV	ubiquitination	[2]
226	DKYEEEIKVLSDKLK	ubiquitination	[2]
231	EIKVLSDKLKEAETR	acetylation	[3]
231	EIKVLSDKLKEAETR	ubiquitination	[2]
233	KVLSDKLKEAETRAE	acetylation	[3]
233	KVLSDKLKEAETRAE	ubiquitination	[2]
248	FAERSVTKLEKSIDD	acetylation	[3]
248	FAERSVTKLEKSIDD	ubiquitination	[2]
251	RSVTKLEKSIDDLEE	acetylation	[1, 5]
259	SIDDLEEKVAHAKEE	acetylation	[1, 5]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005862; C:muscle thin filament tropomyosin; TAS:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.