CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035667
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Iars2 
Protein Synonyms/Alias
  
Gene Name
 Iars2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
194FAQAAIEKQKSAFARacetylation[1]
222FDPKYEAKQLRVFQQacetylation[1]
233VFQQMYEKGLVYRSYacetylation[1]
241GLVYRSYKPVYWSPSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MLWGLHPHGP GTAALTAAGS LWGPARFPSR LGCLGMTRRL VVRSVAGADS PQSSPKSGRY 60
RDTVLLPQTN FPMKLLGHQQ SDMELEIQQK CGFSELYSWQ RERKVKTEFC LHDGPPYANG 120
DPHVGHALNK ILKDIVNRFH MMRGSKVHFV PGWDCHGLPI ETKVLSELGV NTQTLSAMEI 180
REKARSFAQA AIEKQKSAFA RWGVMADWSN CYYTFDPKYE AKQLRVFQQM YEKGLVYRSY 240
KPVYWSPSSR TALAEAELEY NPEHVSRSVY VRFPLLKPPP TLESLTGASS PVSALVWTTQ 300
PWTVPANQAI CYMPEAKYAV VKCSASGNFY ILAEDKISPV ASALETTFDV TATFSGVDLE 360
GGTCSHPLIP DKVSPLLPAT HVTMAKGTGL VHTAPAHGME DYSVASQHSL PMDCLVDEEG 420
MFTSAAGPEL QNKAVLTEGT DV 442 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
 GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR002300; aa-tRNA-synth_Ia.
 IPR002301; Ile-tRNA-ligase.
 IPR023585; Ile-tRNA-ligase_type1.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit. 
Pfam
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR00984; TRNASYNTHILE.