CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016665
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poly [ADP-ribose] polymerase 12 
Protein Synonyms/Alias
 PARP-12; ADP-ribosyltransferase diphtheria toxin-like 12; ARTD12; Zinc finger CCCH domain-containing protein 1 
Gene Name
 Parp12 
Gene Synonyms/Alias
 Zc3hdc1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
251NKGSALSKVSPSPAGubiquitination[1]
456HFKAFLQKNLVYGTIubiquitination[1]
492NTKLHGPKSIPDYWDubiquitination[1]
510LPDLGFKKITLSSSSubiquitination[1]
522SSSEEYQKVWNIFNRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 308 371 WWE 1.
 DOMAIN 374 468 WWE 2.
 DOMAIN 494 708 PARP catalytic.
 ZN_FING 103 128 C3H1-type 1.
 ZN_FING 164 188 C3H1-type 2.
 ZN_FING 189 211 C3H1-type 3.
 ZN_FING 280 307 C3H1-type 4.
 ZN_FING 281 306 C3H1-type 3.  
Keyword
 Complete proteome; Metal-binding; NAD; Nucleus; Reference proteome; Repeat; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 711 AA 
Protein Sequence
MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF VVASRAVVAV 60
GAGREAAAAA SERLVLAVSS LRLCRAHQGP KPGCTGLCAQ LHLCKFLIYG NCKFLKTGKN 120
CRNGHNLKTD HNLSVLRTHG VDHLTYTELC QLLLQNDPSL LPDICLHYNK GDGPFGSCSF 180
QKQCIKLHIC QYFLQGECKF GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY 240
DIKNKGSALS KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC 300
HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH FDNLDFNSMK 360
FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE YGRQGSGHPV TTISSSDVER 420
AYLAFCAPGA DAQAATLKFQ AGKHNYELHF KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM 480
KQSCNTKLHG PKSIPDYWDP AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE 540
RIQNMGLWEV YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS 600
YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK EGQSNAFYDS 660
CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF VALGNLFTSR Q 711 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR004170; WWE-dom.
 IPR000571; Znf_CCCH. 
Pfam
 PF00644; PARP
 PF00642; zf-CCCH 
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS51059; PARP_CATALYTIC
 PS50918; WWE
 PS50103; ZF_C3H1 
PRINTS