CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Early endosome antigen 1 
Protein Synonyms/Alias
  
Gene Name
 Eea1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
100QDLQASLKEEKWYSEubiquitination[1]
115ELKKELEKYQGLQQQubiquitination[1]
228EDVAVLKKELVQVQTubiquitination[1]
995QKTVLENKLQQQSSQubiquitination[1]
1165ITNLKDAKQLLIQQKacetylation[2]
1254NENLGTVKKEWQSSQubiquitination[1]
1312EIEKLQTKALELQRKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking (By similarity). 
Sequence Annotation
 ZN_FING 41 64 C2H2-type.
 ZN_FING 1352 1410 FYVE-type.
 MOD_RES 70 70 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1411 AA 
Protein Sequence
MFRRILQRTP GRVGSQGSDL DSSATPINTV DVNNESSSEG FICPQCMKSL GSADELFKHY 60
QAVHDAGNDS GHGGEAGLAL TRDDITLLRQ EVQDLQASLK EEKWYSEELK KELEKYQGLQ 120
QQEAKSDGLV TDSSAELQAL EQQLEEAQTE NFNIKQMKDL FEQKAAQLAT EIADIKSKYD 180
EEKSLRAAAE QKVTHLTEDL NKQTTVIQDL KTELLQRPGI EDVAVLKKEL VQVQTLMDNM 240
TLERERESEK LKDECKKLQS EHAHLEATIN QLRSELAKGP QEVAVYVQEI QKLKGSINEL 300
TQKNQNLTEK LQKKDLDYTH LEEKHNEESA SRKTLQASLH QRDLDCQQLQ ARLTASESSL 360
QRAQGELSEK AEAAQKLREE LREVESTRQH LKVEVKQLQQ QREEKEQHGL QLQGEVSQLH 420
CKLLETERQL GEAHGRLKEQ RQLSSEKLME KEQQVADLQL KLSRLEEQLK EKVTNSTELQ 480
HQLEKSKQQH QEQQALQQSA TAKLREAQND LEQVLRQIGD KDQKIQNLEA LLQKGKESVS 540
LLEKEREDLY AKIQAGEGET AVLNQLQEKN HALQQQLTQL TEKLKNQSES HKQAEENLHD 600
QVQEQKAHLR AAQDRVLSLE TSVSELSSQL NESKEKVSQL DIQIKAKTEL LLSAEAAKAA 660
QRADLQNHLD TAQHALQDKQ QELNKVSVQL DQLTAKFQEK QEHCIQLESH LKDHKEKHLS 720
LEQKVEDLEG HIKKLEADAL EVKASKEQAL QSLQQQRQLS TDLELRNAEL SRELQEQEEV 780
VSCTKLDLQN KSEILENIKQ TLTKKEEENV VLKQEFEKLS QDSKTQHKEL GDRMQAAVTE 840
LTAVKAQKDA LLAELSTTKE KLSKVSDSLK NSKSEFEKEN QKGKAAVLDL EKACKELKHQ 900
LQVQAESALK EQEDLKKSLE KEKETSQQLK IELNSVKGEV SQAQNTLKQK EKDEQQLQGT 960
INQLKQSAEQ KKKQIEALQG EVKNAVSQKT VLENKLQQQS SQAAQELAAE KGKLSALQSN 1020
YEKCQADLKQ LQSDLYGKES ELLATRQDLK SVEEKLTLAQ EDLISNRNQI GNQNKSIQEL 1080
QAAKASLEQD SAKKEALLKE QSKALEDAQR EKSVKEKELV AEKSKLAEME EIKCRQEKEI 1140
TKLNEELKSH KQESIKEITN LKDAKQLLIQ QKLELQGRVD SLKAALEQEK ESQQLMREQV 1200
KKEEEKRKEE FSEKEAKLHS EIKEKEAGMK KHEENEAKLT MQVTTLNENL GTVKKEWQSS 1260
QRRVSELEKQ TDDLRGEIAV LEATVQNNQD ERRALLERCL KGEGEIEKLQ TKALELQRKL 1320
DNTTAAVQEL GRENQSLQIK HTQALNRKWA EDNEVQNCMS CGKCFSVTVR RHHCRQCGNI 1380
FCAECSTKNA LTPSSKKPVR VCDACFNDLQ G 1411 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0019897; C:extrinsic to plasma membrane; ISS:UniProtKB.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0005969; C:serine-pyruvate aminotransferase complex; IDA:MGI.
 GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006897; P:endocytosis; ISS:UniProtKB.
 GO:0006906; P:vesicle fusion; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE 
SMART
 SM00064; FYVE
 SM00355; ZnF_C2H2 
PROSITE
 PS50178; ZF_FYVE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS