UniProt Accession

 PPID_RAT; Q6DGG0 

Genbank Protein ID

 BC076386 

Genbank Nucleotide ID

 AAH76386.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase D 

Protein Synonyms/Alias

 PPIase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Rotamase D 

Gene Name

 Ppid 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
257	LRYLDSSKAVIEKAD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis. 

Sequence Annotation

 DOMAIN 19 183 PPIase cyclophilin-type.
 REPEAT 223 256 TPR 1.
 REPEAT 273 306 TPR 2.
 REPEAT 308 340 TPR 3.
 REGION 185 215 Chaperone activity (By similarity).
 REGION 214 370 Interaction with HSP90AB1 (By
 MOD_RES 198 198 Phosphoserine (By similarity).  

Keyword

 Apoptosis; Chaperone; Complete proteome; Cyclosporin; Cytoplasm; Direct protein sequencing; Isomerase; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Rotamase; TPR repeat; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0030331; F:estrogen receptor binding; ISS:UniProtKB.
 GO:0030544; F:Hsp70 protein binding; ISS:UniProtKB.
 GO:0051879; F:Hsp90 protein binding; ISS:UniProtKB.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:RGD.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0071492; P:cellular response to UV-A; ISS:UniProtKB.
 GO:0061077; P:chaperone-mediated protein folding; ISS:UniProtKB.
 GO:0034389; P:lipid particle organization; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
 GO:0006461; P:protein complex assembly; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0051881; P:regulation of mitochondrial membrane potential; IMP:RGD.
 GO:0006979; P:response to oxidative stress; IMP:RGD. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR020892; Cyclophilin-type_PPIase_CS.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00160; Pro_isomerase
 PF13176; TPR_7 

SMART

 SM00028; TPR 

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS

 PR00153; CSAPPISMRASE.