UniProt Accession

 ROAA_MOUSE; Q99020; Q8BPE0 

Genbank Protein ID

 D90151; L36663; AK076132 

Genbank Nucleotide ID

 BAA14181.1; AAA92146.1; BAC36208.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein A/B 

Protein Synonyms/Alias

 hnRNP A/B; CArG-binding factor-A; CBF-A 

Gene Name

 Hnrnpab 

Gene Synonyms/Alias

 Cbf-a; Cgbfa; Hnrpab 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
88	GLSWDTSKKDLKDYF	ubiquitination	[1]
92	DTSKKDLKDYFTKFG	ubiquitination	[2]
154	PKKAMAMKKDPVKKI	ubiquitination	[2]
271	QGSTNYGKSQRRGGH	acetylation	[3]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes. 

Sequence Annotation

 DOMAIN 75 158 RRM 1.
 DOMAIN 159 238 RRM 2.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 247 247 Phosphoserine (By similarity).
 MOD_RES 250 250 Dimethylated arginine; alternate (By
 MOD_RES 250 250 Omega-N-methylarginine; alternate (By
 MOD_RES 275 275 Dimethylated arginine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0001837; P:epithelial to mesenchymal transition; IDA:HGNC.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:HGNC.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012956; CARG-binding_factor_N.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF08143; CBFNT
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS