UniProt Accession

 TDRKH_HUMAN; Q9Y2W6; D3DV24; Q5SZR3; Q5SZR5; Q8N582; Q9NYV5 

Genbank Protein ID

 AF119121; AF227192; AL589765; AL589765; CH471121; CH471121; CH471121; BC022467 

Genbank Nucleotide ID

 AAD30971.1; AAF36701.1; CAI17175.1; CAI17177.1; EAW53411.1; EAW53409.1; EAW53410.1 

Protein Name

 Tudor and KH domain-containing protein 

Protein Synonyms/Alias

 Tudor domain-containing protein 2 

Gene Name

 TDRKH 

Gene Synonyms/Alias

 TDRD2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	RVPQEAVKLIIGRQG	ubiquitination	[1]
110	GFPVQVCKAKAAIHQ	ubiquitination	[1]
112	PVQVCKAKAAIHQIL	ubiquitination	[1, 2]
162	GAKITCDKESEGTLL	ubiquitination	[1]
181	IKISGTQKEVAAAKH	ubiquitination	[1]
187	QKEVAAAKHLILEKV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules (By similarity). 

Sequence Annotation

 DOMAIN 52 115 KH 1.
 DOMAIN 124 190 KH 2.
 DOMAIN 353 412 Tudor.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Mitochondrion; Polymorphism; Reference proteome; Repeat; RNA-binding; RNA-mediated gene silencing; Spermatogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 561 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 

Interpro

 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR002999; Tudor. 

Pfam

 PF00013; KH_1
 PF00567; TUDOR 

SMART

 SM00322; KH
 SM00333; TUDOR 

PROSITE

 PS50084; KH_TYPE_1
 PS50304; TUDOR 

PRINTS