UniProt Accession

 ACBD5_HUMAN; Q5T8D3; B3KQ56; D3DRW0; Q5T8D4; Q5T8E1; Q5T8E2; Q86UV1; Q8N6E3; Q9UFB5 

Genbank Protein ID

 AF505653; AK057469; AL160291; AL160291; AL160291; AL160291; AL160291; CH471072; CH471072; CH471072; BC030555; AL133064 

Genbank Nucleotide ID

 AAP30852.1; BAG51918.1; CAI16911.1; CAI16912.1; CAI16913.1; CAI16914.1; CAI16915.1; EAW86062.1; EAW86061.1; EAW86063.1; AAH30555.1; CAB61388.1 

Protein Name

 Acyl-CoA-binding domain-containing protein 5 

Protein Synonyms/Alias

  

Gene Name

 ACBD5 

Gene Synonyms/Alias

 KIAA1996 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
151	FYEIVEDKKSGRSSD	ubiquitination	[1]
185	LTSTPNAKTVNGKAE	ubiquitination	[1]
267	GRSTEEVKPIDENLG	ubiquitination	[1, 2, 3]
378	VEGKGEVKHGGEDGR	ubiquitination	[1]
469	NVLQRLQKLETLTAL	ubiquitination	[1, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters. 

Sequence Annotation

 DOMAIN 41 130 ACB.
 REGION 52 61 Acyl-CoA binding.
 REGION 72 76 Acyl-CoA binding.
 BINDING 98 98 Acyl-CoA.
 BINDING 117 117 Acyl-CoA (By similarity).
 MOD_RES 160 160 Phosphothreonine (By similarity).
 MOD_RES 193 193 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.
 MOD_RES 200 200 Phosphoserine.
 MOD_RES 400 400 Phosphothreonine.
 MOD_RES 428 428 Phosphoserine.
 MOD_RES 441 441 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Lipid-binding; Membrane; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 534 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR016347; M-assoc_diazepam-bd-inh. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.