UniProt Accession

 SOCS2_HUMAN; O14508; A8K3D1; O14542; O95102; Q9UKS5 

Genbank Protein ID

 AB004903; AB006966; AF020590; AF037989; AK290546; AK313165; CH471054; BC010399; AF132441 

Genbank Nucleotide ID

 BAA22429.1; BAA22536.1; AAC98896.1; AAC34745.1; BAF83235.1; BAG35983.1; EAW97492.1; AAH10399.1; AAD27710.1 

Protein Name

 Suppressor of cytokine signaling 2 

Protein Synonyms/Alias

 SOCS-2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2 

Gene Name

 SOCS2 

Gene Synonyms/Alias

 CIS2; SSI2; STATI2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	PQAARLAKALRELGQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 DOMAIN 48 156 SH2.
 DOMAIN 151 197 SOCS box.  

Keyword

 3D-structure; Complete proteome; Growth regulation; Polymorphism; Reference proteome; SH2 domain; Signal transduction inhibitor; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005131; F:growth hormone receptor binding; NAS:UniProtKB.
 GO:0008269; F:JAK pathway signal transduction adaptor activity; TAS:ProtInc.
 GO:0005148; F:prolactin receptor binding; NAS:UniProtKB.
 GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
 GO:0007568; P:aging; IEA:Compara.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
 GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
 GO:0032355; P:response to estradiol stimulus; IDA:BHF-UCL. 

Interpro

 IPR000980; SH2.
 IPR001496; SOCS_C. 

Pfam

 PF00017; SH2
 PF07525; SOCS_box 

SMART

 SM00252; SH2
 SM00253; SOCS
 SM00969; SOCS_box 

PROSITE

 PS50001; SH2
 PS50225; SOCS 

PRINTS

 PR00401; SH2DOMAIN.