UniProt Accession

 FCL_MOUSE; P23591 

Genbank Protein ID

 X53620; X53621; X53622; X53623; X53624; X53625; X53626; X53627; X53628; M30127; M30128; AK029632 

Genbank Nucleotide ID

 CAB94217.1; CAB94217.1; CAB94217.1; CAB94217.1; CAB94217.1; CAB94217.1; CAB94217.1; CAB94217.1; CAB94217.1; AAA39673.2; AAA39674.1; BAC26539.1 

Protein Name

 GDP-L-fucose synthase 

Protein Synonyms/Alias

 GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Transplantation antigen P35B; Tum-P35B antigen 

Gene Name

 Tsta3 

Gene Synonyms/Alias

 P35b; Tstap35b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
108	AFEVGARKVVSCLST	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction (By similarity). 

Sequence Annotation

 NP_BIND 14 20 NADP (By similarity).
 NP_BIND 170 173 NADP (By similarity).
 ACT_SITE 143 143 Proton donor/acceptor (By similarity).
 BINDING 147 147 NADP (By similarity).
 BINDING 186 186 NADP (By similarity).
 BINDING 194 194 Substrate (By similarity).
 BINDING 208 208 Substrate (By similarity).
 BINDING 215 215 Substrate (By similarity).
 BINDING 277 277 Substrate (By similarity).  

Keyword

 Complete proteome; Isomerase; Multifunctional enzyme; NADP; Oxidoreductase; Reference proteome; Tumor antigen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0050577; F:GDP-L-fucose synthase activity; IEA:EC.
 GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
 GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019835; P:cytolysis; IMP:MGI.
 GO:0019673; P:GDP-mannose metabolic process; IEA:Compara. 

Interpro

 IPR001509; Epimerase_deHydtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01370; Epimerase 

SMART

  

PROSITE

  

PRINTS