CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004887
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Argininosuccinate lyase 
Protein Synonyms/Alias
 ASAL; Arginosuccinase 
Gene Name
 Asl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
7*MASESGKLWGGRFAacetylation[1]
43NVDLQGSKAYSRGLEacetylation[1]
97TANERRLKELIGEAAacetylation[1]
323GLPSTYNKDLQEDKEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 MOD_RES 69 69 N6-acetyllysine (By similarity).
 MOD_RES 288 288 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Lyase; Polymorphism; Reference proteome; Urea cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 461 AA 
Protein Sequence
MASESGKLWG GRFAGSVDPT MDKFNSSIAY DRHLWNVDLQ GSKAYSRGLE KAGLLTKAEM 60
QQILQGLDKV AEEWAQGIFK LYPNDEDIHT ANERRLKELI GEAAGKLHTG RSRNDQVVTD 120
LRLWMRQTYS KLSTFLKVLI EAMVDRAEAE CEVLFPGYTH LQRAQPIRWS HWILSHAVAL 180
TRDLERLKEV QKRINVLPLG SGAIAGNPLG VDREFLCAEL NFGAITLNSM DATSERDFVA 240
EFLFWASLCM THLSRMAEDL ILYGTKEFNF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA 300
RRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMT AVLQVATGVI STLQIHRENM 360
AQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVVVAEM KGVALNQLSL QELQTVSPLF 420
SSDVNLVWDY SHSVEQYTAL GGTAQSSVEW QISQVRALLQ M 461 
Gene Ontology
 GO:0070852; C:cell body fiber; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; IDA:RGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0004056; F:argininosuccinate lyase activity; IDA:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0006526; P:arginine biosynthetic process; NAS:RGD.
 GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
 GO:0000053; P:argininosuccinate metabolic process; IDA:RGD.
 GO:0071242; P:cellular response to ammonium ion; IEP:RGD.
 GO:0071320; P:cellular response to cAMP; IEP:RGD.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
 GO:0071377; P:cellular response to glucagon stimulus; IEP:RGD.
 GO:0071456; P:cellular response to hypoxia; IEP:RGD.
 GO:0071346; P:cellular response to interferon-gamma; IEP:RGD.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
 GO:0060539; P:diaphragm development; IEP:RGD.
 GO:0006475; P:internal protein amino acid acetylation; ISS:UniProtKB.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0001889; P:liver development; IDA:RGD.
 GO:0007494; P:midgut development; IEP:RGD.
 GO:0001101; P:response to acid; IEP:RGD.
 GO:0014075; P:response to amine stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0060416; P:response to growth hormone stimulus; IEP:RGD.
 GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0000050; P:urea cycle; IDA:RGD. 
Interpro
 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 
Pfam
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.