| Tag | Content |
|---|
| CPLM ID | CPLM-014349 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Clathrin coat assembly protein AP180 |
Protein Synonyms/Alias | 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180; Phosphoprotein F1-20 |
Gene Name | Snap91 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 134 | YSRYLNEKAFSYRQM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats. |
Sequence Annotation | DOMAIN 14 145 ENTH.
MOD_RES 306 306 Phosphoserine (By similarity).
MOD_RES 312 312 Phosphothreonine.
MOD_RES 313 313 Phosphoserine.
MOD_RES 316 316 Phosphoserine.
MOD_RES 600 600 Phosphoserine.
MOD_RES 621 621 Phosphoserine (By similarity).
MOD_RES 627 627 Phosphoserine (By similarity).
CARBOHYD 310 310 O-linked (GlcNAc) (By similarity). |
Keyword | Alternative splicing; Cell membrane; Coated pit; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 901 AA |
Protein Sequence | MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN ETNVNIPQMA 60
DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR NTLFNLSNFL DKSGSHGYDM 120
STFIRRYSRY LNEKAFSYRQ MAFDFARVKK GADGVMRTMV PEKLLKSMPI LQGQIDALLE 180
FDVHPNELTN GVINAAFMLL FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF 240
LTRMTRVSEF LKVAEQVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNNEGSGAPS 300
PLSKSSPATT VTSPNSTPAK TIDTSPPVDI FATASAAAPV SSAKPSSDLL DLQPDFSGAA 360
AGAAAPVVPP SGGATAWGDL LGEDSLAALS SVPCEAPISD PFAPEPSPPT TTTEPASASA 420
STTTAVTAVT TEVDLFGDAF AASPGEAPAA SEGATAPATP APVAAALDAC SGNDPFAPSE 480
GSAEAAPELD LFAMKPPETS APVVTPTAST APPVPATAPS PAPTAVAATA ATTTAAAAAT 540
TTATTSAAAA TTAAAPPALD IFGDLFDSAP EVAAAPKPDA APSIDLFGTD AFSSPPRGAS 600
PVPESSLTAD LLSVDAFAAP SPASTASPAK AESSGVIDLF GDAFGSGASE TQPAPQAVSS 660
SSASADLLAG FGGSFMAPST TPVTPAQNNL LQPSFEAAFG TTPSTSSSSS FDPSVFDGLG 720
DLLMPTMAPS GQPAPVSMVP PSPAMAASKG LGSDLDSSLA SLVGNLGISG TTSKKGDLQW 780
NAGEKKLTGG ANWQPKVTPA TWSAGVPPQG TVPPTSSVPP GAGAPSVGQP GAGFGMPPSG 840
TGMTMMSQQP VMFAQPMMRP PFGAAAVPGT QLSPSPTPAT QSPKKPPAKD PLADLNIKDF 900
L 901 |
Gene Ontology | GO:0030122; C:AP-2 adaptor complex; IC:BHF-UCL. GO:0005545; F:1-phosphatidylinositol binding; IDA:BHF-UCL. GO:0048268; P:clathrin coat assembly; IDA:BHF-UCL. GO:0007269; P:neurotransmitter secretion; IMP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |