UniProt Accession

 LUXS_SALTY; Q9L4T0 

Genbank Protein ID

 AF268390; AE006468 

Genbank Nucleotide ID

 AAF73475.1; AAL21702.1 

Protein Name

 S-ribosylhomocysteine lyase 

Protein Synonyms/Alias

 AI-2 synthesis protein; Autoinducer-2 production protein LuxS 

Gene Name

 luxS 

Gene Synonyms/Alias

 STM2817 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
23	APAVRVAKTMNTPHG	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity). 

Sequence Annotation

 METAL 54 54 Iron (By similarity).
 METAL 58 58 Iron (By similarity).
 METAL 128 128 Iron (By similarity).  

Keyword

 Autoinducer synthesis; Complete proteome; Iron; Lyase; Metal-binding; Quorum sensing; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0043768; F:S-ribosylhomocysteine lyase activity; IEA:HAMAP.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0009372; P:quorum sensing; IEA:HAMAP. 

Interpro

 IPR011249; Metalloenz_LuxS/M16.
 IPR003815; S-ribosylhomocysteinase. 

Pfam

 PF02664; LuxS 

SMART

  

PROSITE

  

PRINTS

 PR01487; LUXSPROTEIN.