CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037043
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transmembrane and ubiquitin-like domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 TMUB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
122GLITVRLKFLNDTEEubiquitination[1]
143EDTVGALKSKYFPGQubiquitination[2, 3]
145TVGALKSKYFPGQESubiquitination[4]
155PGQESQMKLIYQGRLubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 264 AA 
Protein Sequence
MELSDVTLIE GVGNEVMVVA GVVVLILALV LAWLSTYVAD SGSNQLLGAI VSAGDTSVLH 60
LGHVDHLVAG QGNPEPTELP HPSEGLPKRQ AGAGSSSPEA PLRSEDSTCL PPSPGLITVR 120
LKFLNDTEEL AVARPEDTVG ALKSKYFPGQ ESQMKLIYQG RLLQDPARTL RSLNITDNCV 180
IHCHRSPPGS AVPGPSASLA PSATEPPSLG VNVGSLMVPV FVVLLGVVWY FRINYRQFFT 240
APATVSLVGV TVFFSFLVFG MYGR 264 
Gene Ontology
  
Interpro
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF00240; ubiquitin 
SMART
 SM00213; UBQ 
PROSITE
 PS50053; UBIQUITIN_2 
PRINTS