CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015274
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable ATP-dependent RNA helicase DHX40 
Protein Synonyms/Alias
 DEAH box protein 40 
Gene Name
 Dhx40 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142RFDDCSSKETAIKYMubiquitination[1]
367VVDGGFVKQLNHNPRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Probable ATP-dependent RNA helicase (By similarity). 
Sequence Annotation
 DOMAIN 63 231 Helicase ATP-binding.
 DOMAIN 263 442 Helicase C-terminal.
 NP_BIND 76 83 ATP (By similarity).
 MOTIF 173 176 DEAH box.  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 779 AA 
Protein Sequence
MSRFPAVAGR APRRQEEGER PIELQEERPS AVRIADREEK GCTSQEGGTT PTFPIQKQRK 60
KLIQAVRDNS FLIVTGNTGS GKTTQLPKYL YEAGFSQHGM IGVTQPRKVA AISVAQRVAE 120
EMKCTLGSKV GYQVRFDDCS SKETAIKYMT DGCLLKHILG DPNLSKFSVI ILDEAHERTL 180
TTDILFGLLK KLFQDKSPNR KEHLKVVVMS ATMELAKLSA FFGNCPIFDI PGRLYPVREK 240
FCNLIGPRDR ENTAYIQAIV KVTMDIHLNE MAGDILVFLT GQFEIEKSCE LLFQMAESVD 300
YDYDVQDTTL DGLLILPCYG SMTTDQQRRI FLPPPPGIRK CVISTNISAT SLTIDGIRYV 360
VDGGFVKQLN HNPRLGLDIL EVVPISKSEA LQRSGRAGRT ASGKCFRIYS KEFWSQCMPD 420
HVIPEIKRTS LTSVVLTLKC LAIHDVIRFP YLDPPNERLI LEALKQLYQC DAIDRSGHVT 480
RLGLSMVEFP LPPHLTCAVI RAASLDCEDL LLPIAAMLSV ENVFIRPVDP EYQKEAEQRH 540
RELAAKAGGF NDFATLAVIF EQCKSSGAPA SWCQKHWIHW RCLFSAFRVE AQLRELIRKL 600
KQQSDFPRET FEGPKHEVLR RCLCAGYFKN VARRSVGRTF CTMDGRGSPV HIHPSSALHE 660
QETKLEWIIF HEVLVTTKVY ARIVCPIRYE WVRDLLPKLH ELNAHDLSSV ARREMREDAR 720
RKWTNKENVK QLKDGISKEV LKKMQRRNDD KSISDARARF LERKQQRIQD HSDTLKETG 779 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR002464; DNA/RNA_helicase_DEAH_CS.
 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 
SMART
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS00690; DEAH_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS