CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018292
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase TRIM41 
Protein Synonyms/Alias
 RING finger-interacting protein with C kinase; RINCK; Tripartite motif-containing protein 41 
Gene Name
 TRIM41 
Gene Synonyms/Alias
 RINCK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
229TDQGICPKHQEALKLubiquitination[1]
235PKHQEALKLFCEVDEubiquitination[1]
256CRESRSHKQHSVVPLubiquitination[1]
271EEVVQEYKAKLQGHVubiquitination[1]
273VVQEYKAKLQGHVEPubiquitination[1]
290KHLEAVQKMKAKEERubiquitination[1]
303ERRVTELKSQMKSELubiquitination[1]
307TELKSQMKSELAAVAubiquitination[1, 2]
383LRLLQDIKETFNRCEubiquitination[1, 2, 3]
512ESTHHKEKVGPGGSSubiquitination[1, 3, 4]
557WCVGTNGKRYQAQSSubiquitination[1, 4]
575TLLSPSEKPRRFGVYubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. 
Sequence Annotation
 DOMAIN 413 630 B30.2/SPRY.
 ZN_FING 20 61 RING-type.
 ZN_FING 222 263 B box-type.
 MOD_RES 447 447 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Ligase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 630 AA 
Protein Sequence
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG EDEEDRDELD 60
REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE EEEEGVFWTS GMSRSSWDNM 120
DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC 180
FTCPQCRKSF PRRSFRPNLQ LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV 240
DEEAICVVCR ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT 300
ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA SRLAEQAAQL 360
SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW SPDPCQPHSH DFLTDAIVRK 420
MSRMFCQAAR VDLTLDPDTA HPALMLSPDR RGVRLAERRQ EVADHPKRFS ADCCVLGAQG 480
FRSGRHYWEV EVGGRRGWAV GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP 540
QQPLLQREVW CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH 600
VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP 630 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR006574; PRY.
 IPR003877; SPRY_rcpt.
 IPR000315; Znf_B-box.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00622; SPRY
 PF00643; zf-B_box
 PF00097; zf-C3HC4 
SMART
 SM00336; BBOX
 SM00589; PRY
 SM00184; RING 
PROSITE
 PS50188; B302_SPRY
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS
 PR01407; BUTYPHLNCDUF.