UniProt Accession

 F7CFA5_MOUSE; F7CFA5 

Genbank Protein ID

 AC160930 

Genbank Nucleotide ID

  

Protein Name

 Glutamate dehydrogenase 1, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Glud1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	YLHRFGAKCVGVGES	acetylation	[1, 2, 3, 4]
28	YLHRFGAKCVGVGES	succinylation	[3]
28	YLHRFGAKCVGVGES	ubiquitination	[5]
48	NPDGIDPKELEDFKL	acetylation	[1, 2, 3, 4, 6, 7, 8]
48	NPDGIDPKELEDFKL	succinylation	[3]
54	PKELEDFKLQHGSIL	acetylation	[1, 2, 3, 4, 6, 8]
54	PKELEDFKLQHGSIL	succinylation	[3]
54	PKELEDFKLQHGSIL	ubiquitination	[5]
65	GSILGFPKAKVYEGS	acetylation	[2, 3, 4, 6]
65	GSILGFPKAKVYEGS	succinylation	[3]
65	GSILGFPKAKVYEGS	ubiquitination	[5]
67	ILGFPKAKVYEGSIL	acetylation	[2, 3, 4]
67	ILGFPKAKVYEGSIL	succinylation	[3]
88	LIPAASEKQLTKSNA	acetylation	[4]
92	ASEKQLTKSNAPRVK	acetylation	[2, 3, 4]
92	ASEKQLTKSNAPRVK	succinylation	[3]
101	NAPRVKAKIIAEGAN	acetylation	[1, 2, 4]
101	NAPRVKAKIIAEGAN	ubiquitination	[5]
117	PTTPEADKIFLERNI	acetylation	[1, 2, 3, 4, 6, 7, 8]
117	PTTPEADKIFLERNI	succinylation	[3]
117	PTTPEADKIFLERNI	ubiquitination	[5]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [6] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0004353; F:glutamate dehydrogenase [NAD(P)+] activity; IDA:MGI.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
 GO:0032024; P:positive regulation of insulin secretion; IGI:MGI. 

Interpro

 IPR006096; Glu/Leu/Phe/Val_DH_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00208; ELFV_dehydrog 

SMART

 SM00839; ELFV_dehydrog 

PROSITE

  

PRINTS