CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Meiotic sister-chromatid recombination protein 3 
Protein Synonyms/Alias
  
Gene Name
 MSC3 
Gene Synonyms/Alias
 YLR219W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
99AAKQYSQKTYSLRSQacetylation[1]
159RANSITVKTTQVTDPubiquitination[2]
180ITKKTIRKINGYEYVubiquitination[2]
458ANTGLTDKEMYDQALubiquitination[2]
491DNSTTAAKPRQVGVSubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 May be involved in the control of meiotic sister- chromatid recombination. 
Sequence Annotation
 MOD_RES 57 57 Phosphoserine.
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 127 127 Phosphoserine.
 MOD_RES 151 151 Phosphoserine.
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 363 363 Phosphoserine.
 MOD_RES 646 646 Phosphothreonine.
 MOD_RES 660 660 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; DNA recombination; Meiosis; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 728 AA 
Protein Sequence
MVFGFTKRDR RVPDLSRYDY YYQNHEDYNK SPQLSAAAAS AASAASPDRT NYSRSHSLVS 60
HAPSIPRQRS SVKSPGRRLS TSSAAPPTSR AAAKQYSQKT YSLRSQRSGE YHLHPPGYTT 120
NGSRMNSMTS GANVRRNYGK NKSTAGNNND SRANSITVKT TQVTDPSGRT QSITKKTIRK 180
INGYEYVETT TTTKNLVPLG DSQRHFDEFS ENYMLQDDDI LEEQASDNIH DIIEENETDN 240
EKPYSPVSES HLQDDSELNV EKPDFPLGSY FHHKYSTDVM PLEEESSLSN FSDALDYIPP 300
THQTSSKYIH NKRKQASTTR RKKRPPAVKN AEAEAKKPLT EAEMYLKALE VAKRNVYHTD 360
AASDNASAPL GSNKSRKSRM GQKMTLRSSS DSPTATANLV KSNVEVQPKR FTSSFFSRNT 420
KSAPHEVHNH SVSTHFKSNK AVDPVPEPKS ANTGLTDKEM YDQALKIAQA RYYNSHGIQP 480
EAVDNSTTAA KPRQVGVSHL GSTGSIPPNE QHYLGDSEIP VQSEVHEYEP IPLQKTKTTG 540
SSKNKFKTMF DKVLQFSQEN YGYQHKKEQG EQTPVTRNAE ESFPAASISE GVTTAKPSSN 600
EGVMTNPVVT DSPSPLQQQI DSTTASSNGQ SQGNVPTSAV ASTTRTRSPE LQDNLKSSSS 660
LLQDQTPQRQ EDATDPTTSS TNELSAAEPT MVTSTHATKT IQAQTQDPPT KHKKSSFFTK 720
LFKKKSSR 728 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0007131; P:reciprocal meiotic recombination; IMP:SGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS