| Tag | Content |
|---|
| CPLM ID | CPLM-020220 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Melanophilin |
Protein Synonyms/Alias | Exophilin-3; Slp homolog lacking C2 domains a; SlaC2-a; Synaptotagmin-like protein 2a |
Gene Name | MLPH |
Gene Synonyms/Alias | SLAC2A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 136 | FKRFGSAKVIRSLHG | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. |
Sequence Annotation | DOMAIN 4 124 RabBD.
ZN_FING 64 107 FYVE-type.
MOD_RES 162 162 Phosphoserine (By similarity).
MOD_RES 165 165 Phosphothreonine (By similarity).
MOD_RES 314 314 Phosphoserine (By similarity).
MOD_RES 458 458 Phosphothreonine (By similarity).
MOD_RES 552 552 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 600 AA |
Protein Sequence | MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEALK GKIKKESSKR ELLSDTAHLN 60
ETHCARCLQP YQLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW 120
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PELISEERSG DSDQTDEDGE PGSEAQAQAQ 180
PFGSKKKRLL SVHDFDFEGD SDDSTQPQGH SLHLSSVPEA RDSPQSLTDE SCSEKAAPHK 240
AEGLEEADTG ASGCHSHPEE QPTSISPSRH GALAELCPPG GSHRMALGTA AALGSNVIRN 300
EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ IFELNKHISA VECLLTYLEN 360
TVVPPLAKGL GAGVRTEADV EEEALRRKLE ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS 420
VGPLPQADPE VGTAAHQTNR QEKSPQDPGD PVQYNRTTDE ELSELEDRVA VTASEVQQAE 480
SEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA 540
MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS 600 |
Gene Ontology | GO:0030864; C:cortical actin cytoskeleton; IEA:Compara. GO:0005815; C:microtubule organizing center; IEA:Compara. GO:0035371; C:microtubule plus end; IEA:Compara. GO:0001725; C:stress fiber; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030318; P:melanocyte differentiation; IEA:Compara. GO:0032400; P:melanosome localization; IEA:Compara. GO:0006605; P:protein targeting; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |