UniProt Accession

 RAB5A_CANFA; P18066 

Genbank Protein ID

 M35520 

Genbank Nucleotide ID

 AAA30889.1 

Protein Name

 Ras-related protein Rab-5A 

Protein Synonyms/Alias

  

Gene Name

 RAB5A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Canis familiaris (Dog) (Canis lupus familiaris) 

NCBI Taxa ID

 9615 

Lysine Modification

Position	Peptide	Type	References
134	VIALSGNKADLANKR	ubiquitination	[1]
140	NKADLANKRAVDFQE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension (By similarity). 

Sequence Annotation

 NP_BIND 27 35 GTP (By similarity).
 NP_BIND 75 79 GTP (By similarity).
 NP_BIND 133 136 GTP (By similarity).
 NP_BIND 163 165 GTP (By similarity).
 MOTIF 49 57 Effector region (Potential).
 LIPID 212 212 S-geranylgeranyl cysteine (By
 LIPID 213 213 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Cell projection; Complete proteome; Cytoplasmic vesicle; Differentiation; Endosome; GTP-binding; Lipoprotein; Membrane; Neurogenesis; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; ISS:UniProtKB.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0045921; P:positive regulation of exocytosis; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:2000286; P:receptor internalization involved in canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0051489; P:regulation of filopodium assembly; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.