| Tag | Content |
|---|
| CPLM ID | CPLM-018353 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MAP kinase-activating death domain protein |
Protein Synonyms/Alias | Differentially expressed in normal and neoplastic cells; Insulinoma glucagonoma clone 20; Rab3 GDP/GTP exchange factor |
Gene Name | MADD |
Gene Synonyms/Alias | DENN; IG20; KIAA0358 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 425 | EPESLELKKHLKQAL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. |
Sequence Annotation | DOMAIN 25 98 UDENN.
DOMAIN 172 402 DENN.
DOMAIN 485 558 dDENN.
DOMAIN 1340 1415 Death.
MOD_RES 813 813 Phosphoserine (By similarity).
MOD_RES 818 818 Phosphoserine.
MOD_RES 820 820 Phosphoserine.
MOD_RES 921 921 Phosphoserine.
MOD_RES 1059 1059 Phosphoserine (By similarity).
MOD_RES 1061 1061 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1647 AA |
Protein Sequence | MVQKKKFCPR LLDYLVIVGA RHPSSDSVAQ TPELLRRYPL EDHTEFPLPP DVVFFCQPEG 60
CLSVRQRRMS LRDDTSFVFT LTDKDTGVTR YGICVNFYRS FQKRISKEKG EGGAGSRGKE 120
GTHATCASEE GGTESSESGS SLQPLSADST PDVNQSPRGK RRAKAGSRSR NSTLTSLCVL 180
SHYPFFSTFR ECLYTLKRLV DCCSERLLGK KLGIPRGVQR DTMWRIFTGS LLVEEKSSAL 240
LHDLREIEAW IYRLLRSPVP VSGQKRVDIE VLPQELQPAL TFALPDPSRF TLVDFPLHLP 300
LELLGVDACL QVLTCILLEH KVVLQSRDYN ALSMSVMAFV AMIYPLEYMF PVIPLLPTCM 360
ASAEQLLLAP TPYIIGVPAS FFLYKLDFKM PDDVWLVDLD SNRVIAPTNA EVLPILPEPE 420
SLELKKHLKQ ALASMSLNTQ PILNLEKFHE GQEIPLLLGR PSNDLQSTPS TEFNPLIYGN 480
DVDSVDVATR VAMVRFFNSA NVLQGFQMHT RTLRLFPRPV VAFQAGSFLA SRPRQTPFAE 540
KLARTQAVEY FGEWILNPTN YAFQRIHNNM FDPALIGDKP KWYAHQLQPI HYRVYDSNSQ 600
LAEALSVPPE RDSDSEPTDD SGSDSMDYDD SSSSYSSLGD FVSEMMKCDI NGDTPNVDPL 660
THAALGDASE VEIDELQNQK EAEEPGPDSE NSQENPPLRS SSSTTASSSP STVIHGANSE 720
PADSTEMDDK AAVGVSKPLP SVPPSIGKSN VDRRQAEIGE GSVRRRIYDN PYFEPQYGFP 780
PEEDEDEQGE SYTPRFSQHV SGNRAQKLLR PNSLRLASDS DAESDSRASS PNSTVSNTST 840
EGFGGIMSFA SSLYRNHSTS FSLSNLTLPT KGAREKATPF PSLKVFGLNT LMEIVTEAGP 900
GSGEGNRRAL VDQKSSVIKH SPTVKREPPS PQGRSSNSSE NQQFLKEVVH SVLDGQGVGW 960
LNMKKVRRLL ESEQLRVFVL SKLNRMVQSE DDARQDIIPD VEISRKVYKG MLDLLKCTVL 1020
SLEQSYAHAG LGGMASIFGL LEIAQTHYYS KEPDKRKRSP TESVNTPVGK DPGLAGRGDP 1080
KAMAQLRVPQ LGPRAPSATG KGPKELDTRS LKEENFIASI GPEVIKPVFD LGETEEKKSQ 1140
ISADSGVSLT SSSQRTDQDS VIGVSPAVMI RSSSQDSEVS TVVSNSSGET LGADSDLSSN 1200
AGDGPGGEGS VHLASSRGTL SDSEIETNSA TSTIFGKAHS LKPSIKEKLA GSPIRTSEDV 1260
SQRVYLYEGL LGKERSTLWD QMQFWEDAFL DAVMLEREGM GMDQGPQEMI DRYLSLGEHD 1320
RKRLEDDEDR LLATLLHNLI SYMLLMKVNK NDIRKKVRRL MGKSHIGLVY SQQINEVLDQ 1380
LANLNGRDLS IWSSGSRHMK KQTFVVHAGT DTNGDIFFME VCDDCVVLRS NIGTVYERWW 1440
YEKLINMTYC PKTKVLCLWR RNGSETQLNK FYTKKCRELY YCVKDSMERA AARQQSIKPG 1500
PELGGEFPVQ DLKTGEGGLL QVTLEGINLK FMHNQVFIEL NHIKKCNTVR GVFVLEEFVP 1560
EIKEVVSHKY KTPMAHEICY SVLCLFSYVA AVHSSEEDLR TPPRPVSS 1608 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0016021; C:integral to membrane; IDA:UniProtKB. GO:0005886; C:plasma membrane; IDA:HPA. GO:0005123; F:death receptor binding; TAS:ProtInc. GO:0030295; F:protein kinase activator activity; TAS:UniProtKB. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB. GO:0000187; P:activation of MAPK activity; IMP:UniProtKB. GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc. GO:0097194; P:execution phase of apoptosis; IMP:UniProtKB. GO:0051726; P:regulation of cell cycle; IMP:UniProtKB. GO:1902041; P:regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |