CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028887
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphoglucomutase-1 
Protein Synonyms/Alias
  
Gene Name
 Pgm2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
164APEAITDKIFQISKTubiquitination[1]
170DKIFQISKTIEEYAIacetylation[2]
182YAICPDLKVDLGVLGacetylation[3]
190VDLGVLGKQQFDLENubiquitination[1]
227IFDFNALKELLSGPNacetylation[3]
252GVVGPYVKKILCEELacetylation[2, 3]
252GVVGPYVKKILCEELubiquitination[1]
367DRVANATKIALYETPacetylation[3, 4]
367DRVANATKIALYETPubiquitination[1]
378YETPTGWKFFGNLMDubiquitination[1]
432QSVEDILKDHWQKFGacetylation[3]
432QSVEDILKDHWQKFGubiquitination[1]
437ILKDHWQKFGRNFFTacetylation[2, 4]
437ILKDHWQKFGRNFFTsuccinylation[4]
437ILKDHWQKFGRNFFTubiquitination[1]
458VEAEGANKMMKDLEAubiquitination[1]
461EGANKMMKDLEALMLacetylation[2]
461EGANKMMKDLEALMLubiquitination[1]
475LDRSFVGKQFSANDKacetylation[2, 3]
475LDRSFVGKQFSANDKubiquitination[1]
482KQFSANDKVYTVEKAacetylation[3]
488DKVYTVEKADNFEYSacetylation[3]
488DKVYTVEKADNFEYSubiquitination[1]
504PVDGSISKNQGLRLIacetylation[2, 3]
504PVDGSISKNQGLRLIubiquitination[1]
541LYIDSYEKDVAKINQacetylation[3]
541LYIDSYEKDVAKINQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MSDFEEWISG TYRKTEEGPL PLLTFATAPY HDQKPGTSGL RKNTYYFEEK PCYLENFIQS 60
IFFSIDLKDR QGSSLVVGGD GRYFNKSAIE TIVQMAAANG IGRLVIGQNG ILSTPAVSCI 120
IRKIKAIGGI ILTASHNPGG PNGDFGIKFN ISNGGPAPEA ITDKIFQISK TIEEYAICPD 180
LKVDLGVLGK QQFDLENKFK PFTVEIVDSV EAYATMLRNI FDFNALKELL SGPNRLKIRI 240
DAMHGVVGPY VKKILCEELG APANSAVNCV PLEDFGGHHP DPNLTYAADL VETMKSGEHD 300
FGAAFDGDGD RNMILGKHGF FVNPSDSVAV IAANIFSIPY FQQTGVRGFA RSMPTSGALD 360
RVANATKIAL YETPTGWKFF GNLMDASKLS LCGEESFGTG SDHIREKDGL WAVLAWLSIL 420
ATRKQSVEDI LKDHWQKFGR NFFTRYDYEE VEAEGANKMM KDLEALMLDR SFVGKQFSAN 480
DKVYTVEKAD NFEYSDPVDG SISKNQGLRL IFADGSRIIF RLSGTGSAGA TIRLYIDSYE 540
KDVAKINQDP QVMLAPLISI ALKVSQLQER TGRTAPTVIT 580 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004614; F:phosphoglucomutase activity; IDA:MGI.
 GO:0019388; P:galactose catabolic process; IBA:RefGenome.
 GO:0006006; P:glucose metabolic process; IDA:MGI.
 GO:0005978; P:glycogen biosynthetic process; IBA:RefGenome. 
Interpro
 IPR005844; A-D-PHexomutase_a/b/a-I.
 IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
 IPR005845; A-D-PHexomutase_a/b/a-II.
 IPR005846; A-D-PHexomutase_a/b/a-III.
 IPR005843; A-D-PHexomutase_C.
 IPR016066; A-D-PHexomutase_CS.
 IPR005841; Alpha-D-phosphohexomutase_SF. 
Pfam
 PF02878; PGM_PMM_I
 PF02879; PGM_PMM_II
 PF02880; PGM_PMM_III
 PF00408; PGM_PMM_IV 
SMART
  
PROSITE
 PS00710; PGM_PMM 
PRINTS
 PR00509; PGMPMM.