| Tag | Content |
|---|
| CPLM ID | CPLM-000848 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial |
Protein Synonyms/Alias | Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN |
Gene Name | Bckdk |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 163 | RQLLDDHKDVVTLLA | acetylation | [1] | | 184 | RKHIQDEKLVRYFLD | acetylation | [1] | | 192 | LVRYFLDKTLTSRLG | acetylation | [1] | | 233 | SPKKIIEKWVDFARR | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex (By similarity). |
Sequence Annotation | DOMAIN 159 404 Histidine kinase.
MOD_RES 31 31 Phosphoserine.
MOD_RES 35 35 Phosphothreonine.
MOD_RES 52 52 Phosphoserine; by autocatalysis (By
MOD_RES 192 192 N6-acetyllysine (By similarity).
MOD_RES 233 233 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ATP-binding; Complete proteome; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 412 AA |
Protein Sequence | MILTSVLGSG PRSWSSLWPL LGSSLSLRAR STSATDTHHV ELARERSKTV TSFYNQSAID 60
VAAEKPSVRL TPTMMLYSGR SQDGSHLLKS GRYLQQELPV RIAHRIKGFR SLPFIIGCNP 120
TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI 180
QDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR 240
LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI 300
TIANNDIDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRINPLFG HLDMHSGGQS 360
GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI 412 |
Gene Ontology | GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; ISS:HGNC. GO:0047323; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; IEA:EC. GO:0005524; F:ATP binding; ISS:HGNC. GO:0004674; F:protein serine/threonine kinase activity; ISS:HGNC. GO:0009083; P:branched-chain amino acid catabolic process; ISS:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |