| Tag | Content |
|---|
| CPLM ID | CPLM-005725 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Meprin A subunit alpha |
Protein Synonyms/Alias | Endopeptidase-2; MEP-1 |
Gene Name | Mep1a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 633 | ALGESSRKAMLEESL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | DOMAIN 263 432 MAM.
DOMAIN 433 594 MATH.
DOMAIN 671 711 EGF-like.
REGION 65 262 Metalloprotease.
ACT_SITE 155 155 By similarity.
METAL 154 154 Zinc; catalytic (By similarity).
METAL 158 158 Zinc; catalytic (By similarity).
METAL 164 164 Zinc; catalytic (By similarity).
CARBOHYD 28 28 N-linked (GlcNAc...).
CARBOHYD 139 139 N-linked (GlcNAc...).
CARBOHYD 221 221 N-linked (GlcNAc...).
CARBOHYD 257 257 N-linked (GlcNAc...).
CARBOHYD 317 317 N-linked (GlcNAc...).
CARBOHYD 413 413 N-linked (GlcNAc...).
CARBOHYD 439 439 N-linked (GlcNAc...).
CARBOHYD 533 533 N-linked (GlcNAc...).
CARBOHYD 540 540 N-linked (GlcNAc...).
DISULFID 106 258 By similarity.
DISULFID 127 146 By similarity.
DISULFID 268 430 By similarity.
DISULFID 276 276 Interchain (By similarity).
DISULFID 307 307 Interchain (By similarity).
DISULFID 675 686 By similarity.
DISULFID 680 695 By similarity.
DISULFID 697 710 By similarity. |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease; Protease; Reference proteome; Signal; Transmembrane; Transmembrane helix; Zinc; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 747 AA |
Protein Sequence | MLWIQPACLL SLIFSAHIAA VSIKHLLNGS DHDTDVGEQK DIFEINLAAG LNLFQGDILL 60
PRTRNAMRDP SSRWKLPIPY ILADNLELNA KGAILHAFEM FRLKSCVDFK PYEGESSYII 120
FQKLSGCWSM IGDQQVGQNI SIGEGCDFKA TIEHEILHAL GFFHEQSRTD RDDYVNIWWD 180
QIITDYEHNF NTYDDNTITD LNTPYDYESL MHYGPFSFNK NESIPTITTK IPEFNTIIGQ 240
LPDFSAIDLI RLNRMYNCTA THTLLDHCDF EKTNVCGMIQ GTRDDADWAH GDSSQPEQVD 300
HTLVGQCKGA GYFMFFNTSL GARGEAALLE SRILYPKRKQ QCLQFFYKMT GSPADRFEVW 360
VRRDDNAGKV RQLAKIQTFQ GDSDHNWKIA HVTLNEEKKF RYVFLGTKGD PGNSSGGIYL 420
DDITLTETPC PAGVWTIRNI SQILENTVKG DKLVSPRFYN SEGYGVGVTL YPNGRITSNS 480
GFLGLTFHLY SGDNDAILEW PVENRQAIMT ILDQEADTRN RMSLTLMFTT SKNQTSSAIN 540
GSVIWDRPSK VGVYDKDCDC FRSLDWGWGQ AISHQLLKRR NFLKGDSLII FVDFKDLTHL 600
NRTEVPASAR STMPRGLLLQ GQESPALGES SRKAMLEESL PSSLGQRHPS RQKRSVENTG 660
PMEDHNWPQY FRDPCDPNPC QNEGTCVNVK GMASCRCVSG HAFFYAGERC QAMHVHGSLL 720
GLLIGCIAGL IFLTFVTFST TNGKLRQ 747 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |