| Tag | Content |
|---|
| CPLM ID | CPLM-016799 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium uptake protein 2, mitochondrial |
Protein Synonyms/Alias | EF-hand domain-containing family member A1 |
Gene Name | Micu2 |
Gene Synonyms/Alias | Efha1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 211 | QDGFKTVKTNETEYQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU). |
Sequence Annotation | DOMAIN 169 204 EF-hand 1.
DOMAIN 224 259 EF-hand 2.
DOMAIN 290 325 EF-hand 3.
DOMAIN 359 394 EF-hand 4.
MOD_RES 202 202 Phosphoserine (By similarity). |
Keyword | Complete proteome; Mitochondrion; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 432 AA |
Protein Sequence | MAAAAGRSAW LAAWGGRLRR GLAAGRRAVP TRGPLAAAVA GVALAGAGAA WHHGRVKAAA 60
REGSRTVSAQ KNYLGPIEKL SLRKQRFMQF SSLEHDGEYY MTPRDFLFSV MFEQVERKTL 120
VKKLAKKDIE DVLSGIQTAR CGSTFFRDLG DKGVISYTEY LFLLTILTKP HSGFHVAFKM 180
LDVDGNEMIE RKEFVKLQKI ISKQDGFKTV KTNETEYQDP TVKEPGVNTT LQVRFFGKRG 240
EKKLHYKEFR RFMENLQTEV QEMEFLQFSK GLNFMRKEDF AEWLLFFTNT ENKDIYWRNV 300
REKLSVGESI SLDEFKSFCH FTTHLEDFAI AMQMFSLAHR PVRLAEFKRA VKVATGQELS 360
DNLLDTVFKI FDLDGDECLS HGEFLGVLKN RMHRGLWVSQ QQSVQEYWKC VKKESIKGVK 420
EAWRQQAGKG PF 432 |
Gene Ontology | GO:0034704; C:calcium channel complex; IDA:UniProtKB. GO:0005739; C:mitochondrion; IMP:UniProtKB. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0051561; P:elevation of mitochondrial calcium ion concentration; IMP:UniProtKB. GO:0006851; P:mitochondrial calcium ion transport; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |