UniProt Accession

 WRIP1_HUMAN; Q96S55; B2RDB0; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q9H681; Q9NRJ6 

Genbank Protein ID

 AB056152; AK026179; AK315471; AB209723; AK223593; AL139092; AL139092; AL139092; AL139092; CH471087; BC018923; AF218313 

Genbank Nucleotide ID

 BAB60709.1; BAB15383.1; BAG37857.1; BAD92960.1; BAD97313.1; CAH73663.1; CAH73664.1; CAH73665.1; CAH73666.1; EAW55087.1; AAH18923.1; AAF80563.1 

Protein Name

 ATPase WRNIP1 

Protein Synonyms/Alias

 Werner helicase-interacting protein 1 

Gene Name

 WRNIP1 

Gene Synonyms/Alias

 WHIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
225	IRQMLQGKPLADTMR	ubiquitination	[1]
244	QDYFGQSKAVGQDTL	ubiquitination	[1]
286	HIIASNSKKHSIRFV	ubiquitination	[1]
301	TLSATNAKTNDVRDV	ubiquitination	[1]
310	NDVRDVIKQAQNEKS	ubiquitination	[1]
457	LITENDVKEGLQRSH	ubiquitination	[1, 2]
602	NAPTRLMKDLGYGKG	ubiquitination	[1]
608	MKDLGYGKGYKYNPM	ubiquitination	[1]
611	LGYGKGYKYNPMYSE	ubiquitination	[1]
636	LRGVDFFKQRRC***	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis. 

Sequence Annotation

 ZN_FING 17 40 UBZ-type.
 NP_BIND 268 275 ATP (Potential).
 MOD_RES 75 75 Phosphoserine.
 MOD_RES 85 85 Phosphothreonine.
 MOD_RES 91 91 Phosphoserine.
 MOD_RES 92 92 Phosphoserine.
 MOD_RES 116 116 Phosphothreonine.
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 534 534 Phosphotyrosine.
 MOD_RES 562 562 Phosphotyrosine.
 MOD_RES 633 633 N6-acetyllysine; alternate.
 CROSSLNK 81 81 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 141 141 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 225 225 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 301 301 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 310 310 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 316 316 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 322 322 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 335 335 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 482 482 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 627 627 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 633 633 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 636 636 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; DNA damage; DNA replication; Hydrolase; Isopeptide bond; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 665 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IMP:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0000731; P:DNA synthesis involved in DNA repair; IDA:UniProtKB.
 GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IDA:UniProtKB. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR021886; MgsA_C.
 IPR027417; P-loop_NTPase.
 IPR006642; Znf_Rad18_put. 

Pfam

 PF00004; AAA
 PF12002; MgsA_C 

SMART

 SM00382; AAA
 SM00734; ZnF_Rad18 

PROSITE

 PS00674; AAA 

PRINTS