CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028415
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dedicator of cytokinesis protein 8 
Protein Synonyms/Alias
  
Gene Name
 DOCK8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
180PLQNPPIKWAEGHKGubiquitination[1]
361SAAAVSSKLLQARVMubiquitination[1]
393VKNIMSSKIADRNCSubiquitination[2]
1396MHAFPYIKTRISVIQubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1566 AA 
Protein Sequence
MCGEDASNAM PVRRETNICL KSGWAAHPCH FTQVRDSSVY KVRLFQANTA QHVQGLLCPG 60
YQWGNRVIFG KSSGPEFLQE VYTAVTYHNK SPDFYEEVKI KLPAKLTVNH HLLFTFYHIS 120
CQQKQGASVE TLLGYSWLPI LLNERLQTGS YCLPVALEKL PPNYSMHSAE KVPLQNPPIK 180
WAEGHKGVFN IEVQAVSSVH TQDNHLEKFF TLCHSLESQV TFPIRVLDQK ISEMALEHEL 240
KLSIICLNSS RLEPLVLFLH LVLDKLFQLS VQPMVIAGQT ANFSQFAFES VVAIANSLHN 300
SKDLSKDQHG RNCLLASYVH YVFRLPEVQR DVPKSGAPTA LLDPRSYHTY GRTSAAAVSS 360
KLLQARVMSS SNPDLAGTHS AADEEVKNIM SSKIADRNCS RMSYYCSGSS DAPSSPAAPR 420
PASKKHFHEE LALQMVVSTG MVRETVFKYA WFFFELLVKS MAQHVHNMDK RDSFRRTRFS 480
DRFMDDITTI VNVVTSEIAA LLVKPQKENE QAEKMNISLA FFLYDLLSLM DRGFVFNLIR 540
HYCSQLSAKL SNLPTLISMR LEFLRILCSH EHYLNLNLFF MNADTAPTSP CPSISSQNSS 600
SCSSFQDQKI ASMFDLTSEY RQQHFLTGLL FTELAAALDA EGEGISKVQR KAVSAIHSLL 660
SSHDLDPRCV KPEVKVKIAA LYLPLVGIIL DALPQLCDFT VADTRRYRTS GSDEEQEGAG 720
AINQNVALAI AGNNFNLKTS GIVLSSLPYK QYNMLNADTT RNLMICFLWI MKNADQSLIR 780
KWIADLPSTQ LNRILDLLFI CVLCFEYKGK QSSDKVSTQV LQKSRDVKAR LEEALLRGEG 840
ARGEMMRRRA PGNDRFPGLN ENLRWKKEQT HWRQANEKLD KTKAELDQEA LISGNLATEA 900
HLIILDMQEN IIQASSALDC KDSLLGGVLR VLVNSLNCDQ STTYLTHCFA TLRALIAKFG 960
DLLFEEEVEQ CFDLCHQVLH HCSSSMDVTR SQACATLYLL MRFSFGATSN FARVKMQVTM 1020
SLASLVGRAP DFNEEHLRRS LRTILAYSEE DTAMQMTPFP TQVEELLCNL NSILYDTVKM 1080
REFQEDPEML MDLMYRIAKS YQASPDLRLT WLQNMAEKHT KKKCYTEAAM CLVHAAALVA 1140
EYLSMLEDHS YLPVGSVSFQ NISSNVLEES VVSEDTLSPD EDGVCAGQYF TESGLVGLLE 1200
QAAELFSTGG LYETVNEVYK LVIPILEAHR EFRKLTLTHS KLQRAFDSIV NKDHKRMFGT 1260
YFRVGFFGSK FGDLDEQEFV YKEPAITKLP EISHRLEAFY GQCFGAEFVE VIKDSTPVDK 1320
TKLDPNKAYI QITFVEPYFD EYEMKDRVTY FEKNFNLRRF MYTTPFTLEG RPRGELHEQY 1380
RRNTVLTTMH AFPYIKTRIS VIQKEEFVLT PIEVAIEDMK KKTLQLAVAI NQEPPDAKML 1440
QMVLQGSVGA TVNQGPLEVA QVFLAEIPAD PKLYRHHNKL RLCFKEFIMR CGEAVEKNKR 1500
LITADQREYQ QELKKNYNKL KENLRPMIER KIPELYKPIF RVESQKRDSF HRSSFRKCET 1560
QLSQGS 1566 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2 
SMART
  
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2 
PRINTS