CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024380
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AT-rich interactive domain-containing protein 1A 
Protein Synonyms/Alias
 ARID domain-containing protein 1A; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A; Osa homolog 1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1 
Gene Name
 Arid1a 
Gene Synonyms/Alias
 Baf250; Baf250a; Osa1; Smarcf1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
24PPPPSELKKAEQQQRacetylation[1]
69GPPQPLGKELQDGAEacetylation[1]
1663QRRRLTMKDIGTPEAacetylation[2]
1878PCPTPPRKHLTTVEGacetylation[2]
1903PPDGLPEKRITATMDacetylation[3]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 
Sequence Annotation
 DOMAIN 1018 1109 ARID.
 MOTIF 296 300 LXXLL.
 MOTIF 1710 1714 LXXLL.
 MOTIF 1965 1969 LXXLL.
 MOTIF 2083 2087 LXXLL.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 287 287 Phosphothreonine (By similarity).
 MOD_RES 302 302 Phosphoserine (By similarity).
 MOD_RES 365 365 Phosphoserine (By similarity).
 MOD_RES 605 605 Phosphoserine (By similarity).
 MOD_RES 697 697 Phosphoserine (By similarity).
 MOD_RES 699 699 Phosphoserine (By similarity).
 MOD_RES 703 703 Phosphoserine (By similarity).
 MOD_RES 765 765 Phosphoserine (By similarity).
 MOD_RES 773 773 Phosphoserine (By similarity).
 MOD_RES 1185 1185 Phosphoserine (By similarity).
 MOD_RES 1605 1605 Phosphoserine (By similarity).
 MOD_RES 1613 1613 N6-acetyllysine (By similarity).
 MOD_RES 1903 1903 N6-acetyllysine (By similarity).
 MOD_RES 1942 1942 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2283 AA 
Protein Sequence
MAAQVAPAAA SSLGNPPPPP SELKKAEQQQ REEAGGEAAA AAAERGEMKA AAGQESEGPA 60
VGPPQPLGKE LQDGAESNGG GGGGGAGSGG GPGAEPDLKN SNGNAGPRPA LNNNLPEPPG 120
GGGGGGSSSS DGVGAPPHSA AAALPPPAYG FGQAYGRSPS AVAAAAAAVF HQQHGGQQSP 180
GLAALQSGGG GGLEPYAGPQ QNSHDHGFPN HQYNSYYPNR SAYPPPPQAY ALSSPRGGTP 240
GSGAAAAAGS KPPPSSSASA SSSSSSFAQQ RFGAMGGGGP SAAGGGTPQP TATPTLNQLL 300
TSPSSARGYQ GYPGGDYGGG PQDGGAGKGP ADMASQCWGA AAAAAAAAAA VSGGAQQRSH 360
HAPMSPGSSG GGGQPLARTP QSSSPMDQMG KMRPQPYGGT NPYSQQQGPP SGPQQGHGYP 420
GQPYGSQTPQ RYPMTMQGRA QSAMGSLSYA QQIPPYGQQG PSAYGQQGQT PYYNQQSPHP 480
QQQPPYAQQP PSQTPHAQPS YQQQPQTQQP QLQSSQPPYS QQPSQPPHQQ SPTPYPSQQS 540
TTQQHPQSQP PYSQPQAQSP YQQQQPQQPA SSSLSQQAAY PQPQPQQSQQ TAYSQQRFPP 600
PQELSQDSFG SQASSAPSMT SSKGGQEDMN LSLQSRPSSL PDLSGSIDDL PMGTEGALSP 660
GVSTSGISSS QGEQSNPAQS PFSPHTSPHL PGIRGPSPSP VGSPASVAQS RSGPLSPAAV 720
PGNQMPPRPP SGQSDSIMHP SMNQSSIAQD RGYMQRNPQM PQYTSPQPGS ALSPRQPSGG 780
QMHSGVGSYQ QNSMGSYGPQ GSQYGPQGGY PRQPNYNALP NANYPNAGMA GSMNPMGAGG 840
QMHGQPGIPP YGTLPPGRMA HASMGNRPYG PNMANMPPQV GSGMCPPPGG MNRKTQESAV 900
AMHVAANSIQ NRPPGYPNMN QGGMMGTGPP YGQGINSMAG MINPQGPPYP MGGTMANNSA 960
GMAASPEMMG LGDVKLTPAT KMNNKADGTP KTESKSKKSS SSTTTNEKIT KLYELGGEPE 1020
RKMWVDRYLA FTEEKAMGMT NLPAVGRKPL DLYRLYVSVK EIGGLTQVNK NKKWRELATN 1080
LNVGTSSSAA SSLKKQYIQC LYAFECKIER GEDPPPDIFA AADSKKSQPK IQPPSPAGSG 1140
SMQGPQTPQS TSSSMAEGGD LKPPTPASTP HSQIPPLPGM SRSNSVGIQD AFPDGSDPTF 1200
QKRNSMTPNP GYQPSMNTSD MMGRMSYEPN KDPYGSMRKA PGSDPFMSSG QGPNGGMGDP 1260
YSRAAGPGLG SVAMGPRQHY PYGGPYDRVR TEPGIGPEGN MGTGAPQPNL MPSTPDSGMY 1320
SPSRYPPQQQ QQQQQQHDSY GNQFSTQGTP SSSPFPSQQT TMYQQQQQNY KRPMDGTYGP 1380
PAKRHEGEMY SVPYSAGQGQ PQQQQLPAAQ SQPASQPQAA QPSPQQDVYN QYSNAYPASA 1440
TAATDRRPAG GPQNQFPFQF GRDRVSAPPG SSAQQNMPPQ MMGGPIQASA EVAQQGTMWQ 1500
GRNDMTYNYA NRQNTGSATQ GPAYHGVNRT DEMLHTDQRA NHEGPWPSHG TRQPPYGPSA 1560
PVPPMTRPPP SNYQPPPSMP NHIPQVSSPA PLPRPMENRT SPSKSPFLHS GMKMQKAGPP 1620
VPASHIAPTP VQPPMIRRDI TFPPGSVEAT QPVLKQRRRL TMKDIGTPEA WRVMMSLKSG 1680
LLAESTWALD TINILLYDDN SIMTFNLSQL PGLLELLVEY FRRCLIEIFG ILKEYEVGDP 1740
GQRTLLDPGR FTKVYSPAHT EEEEEEHLDP KLEEEEEEGV GNDEEMAFLG KDKPSSENNE 1800
EKLVSKFDKL PVKIVQRNDP FVVDCSDKLG RVQEFDSGLL HWRIGGGDTT EHIQTHFESK 1860
IELLPSRPYV PCPTPPRKHL TTVEGTPGTT EQEGPPPDGL PEKRITATMD DMLSTRSSTL 1920
TDEGAKSAEA TKESSKFPFG ISPAQSHRNI KILEDEPHSK DETPLCTLLD WQDSLAKRCV 1980
CVSNTIRSLS FVPGNDFEMS KHPGLLLILG KLILLHHKHP ERKQAPLTYE KEEEQDQGVS 2040
CDKVEWWWDC LEMLRENTLV TLANISGQLD LSPYPESICL PVLDGLLHWA VCPSAEAQDP 2100
FSTLGPNAVL SPQRLVLETL SKLSIQDNNV DLILATPPFS RLEKLYSTMV RFLSDRKNPV 2160
CREMAVVLLA NLAQGDSLAA RAIAVQKGSI GNLLGFLEDS LAATQFQQSQ ASLLHMQNPP 2220
FEPTSVDMMR RAARALLALA KVDENHSEFT LYESRLLDIS VSPLMNSLVS QVICDVLFLI 2280
GQS 2283 
Gene Ontology
 GO:0071565; C:nBAF complex; IDA:UniProtKB.
 GO:0071564; C:npBAF complex; IDA:UniProtKB.
 GO:0000790; C:nuclear chromatin; IDA:MGI.
 GO:0016514; C:SWI/SNF complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030521; P:androgen receptor signaling pathway; ISS:UniProtKB.
 GO:0043044; P:ATP-dependent chromatin remodeling; IDA:MGI.
 GO:0003205; P:cardiac chamber development; IMP:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0042921; P:glucocorticoid receptor signaling pathway; IEA:Compara.
 GO:0030520; P:intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0006337; P:nucleosome disassembly; IEA:Compara.
 GO:0003408; P:optic cup formation involved in camera-type eye development; IMP:MGI.
 GO:0060674; P:placenta blood vessel development; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001606; ARID/BRIGHT_DNA-bd.
 IPR021906; DUF3518. 
Pfam
 PF01388; ARID
 PF12031; DUF3518 
SMART
 SM00501; BRIGHT 
PROSITE
 PS51011; ARID 
PRINTS