CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031556
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Segment polarity protein dishevelled homolog DVL-3 
Protein Synonyms/Alias
 cDNA FLJ61571, highly similar to Segment polarity protein dishevelled homolog DVL-3 
Gene Name
 DVL3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34RVTLADFKGVLQRPSubiquitination[1]
283IYIGSIMKGGAVAADubiquitination[1, 2, 3, 4]
325VLREIVHKPGPITLTubiquitination[4]
449TDRREARKYASNLLKubiquitination[1]
456KYASNLLKAGFIRHTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 699 AA 
Protein Sequence
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 60
SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH 120
AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM 180
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 240
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 300
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRT MTGTFPAYGM 360
SPSLSTITST SSSITSSIPD TERLDDFHLS IHSDMAAIVK AMASPESGLE VRDRMWLKIT 420
IPNAFIGSDV VDWLYHNVEG FTDRREARKY ASNLLKAGFI RHTVNKITFS EQCYYIFGDL 480
CGNMANLSLH DHDGSSGASD QDTLAPLPHP GAAPWPMAFP YQYPPPPHPY NPHPGFPELG 540
YSYGGGSASS QHSEGSRSSG SNRSGSDRRK EKDPKAGDSK SGGSGSESDH TTRSSLRGPR 600
ERAPSERSGP AASEHSHRSH HSLASSLRSH HTHPSYGPPG VPPLYGPPML MMPPPPAAMG 660
PPGAPPGRDL ASVPPELTAS RQSFRMAMGN PSEFFVDVM 699 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:InterPro. 
Interpro
 IPR000591; DEP_dom.
 IPR008342; Dishevelled_3.
 IPR024580; Dishevelled_C-dom.
 IPR008339; Dishevelled_fam.
 IPR003351; Dishevelled_protein_dom.
 IPR001158; DIX.
 IPR015506; Dsh/Dvl-rel.
 IPR001478; PDZ.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF02377; Dishevelled
 PF00778; DIX
 PF12316; Dsh_C
 PF00595; PDZ 
SMART
 SM00021; DAX
 SM00049; DEP
 SM00228; PDZ 
PROSITE
 PS50186; DEP
 PS50841; DIX
 PS50106; PDZ 
PRINTS
 PR01760; DISHEVELLED.
 PR01763; DISHEVELLED3.