UniProt Accession

 HDHD2_HUMAN; Q9H0R4; A8K7T3; Q96NV4 

Genbank Protein ID

 AL136681; AK054590; AK292098; CR533487; CH471096; BC011894; BC033031; BC038100 

Genbank Nucleotide ID

 CAB66616.1; BAB70768.1; BAF84787.1; CAG38518.1; EAW62905.1; AAH11894.1; AAH33031.1; AAH38100.1 

Protein Name

 Haloacid dehalogenase-like hydrolase domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 HDHD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	TNTTKESKQDLLERL	ubiquitination	[1]
145	APLIAIHKARYYKRK	ubiquitination	[1]
182	TVVGKPEKTFFLEAL	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 REGION 13 15 Substrate binding (By similarity).
 REGION 46 47 Substrate binding (By similarity).
 METAL 13 13 Magnesium (By similarity).
 METAL 15 15 Magnesium; via carbonyl oxygen (By
 METAL 204 204 Magnesium (By similarity).
 BINDING 179 179 Substrate (By similarity).  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Magnesium; Metal-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006357; HAD-SF_hydro_IIA.
 IPR006355; HAD-SF_hydro_IIA_hyp2.
 IPR023215; NPhePase-like_dom. 

Pfam

 PF13344; Hydrolase_6 

SMART

  

PROSITE

  

PRINTS