CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037053
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pleckstrin homology domain-containing family G member 2 
Protein Synonyms/Alias
  
Gene Name
 PLEKHG2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
327VSDLTIPKHRHLLQAubiquitination[1]
335HRHLLQAKNQEEKRLubiquitination[1]
362HPASIPAKAKQVLLEubiquitination[1]
364ASIPAKAKQVLLENSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1237 AA 
Protein Sequence
MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTGSAR PSRLERVARE IVETERAYVR 60
DLRSIVEDYL GPLLDGGVLG LSVEQVGTLF ANIEDIYEFS SELLEDLENS SSAGGIAECF 120
VQRSEDFDIY TLYCMNYPSS LALLRELSLS PPAALWLQER QAQLRHSLPL QSFLLKPVQR 180
ILKYHLLLQE LGKHWAEGPG TGGREMVEEA IVSMTAVAWY INDMKRKQEH AARLQEVQRR 240
LGGWTGPELS AFGELVLEGA FRGGGGGGPR LRGGERLLFL FSRMLLVAKR RGLEYTYKGH 300
IFCCNLSVSE SPRDPLGFKV SDLTIPKHRH LLQAKNQEEK RLWIHCLQRL FFENHPASIP 360
AKAKQVLLEN SLHCAPKSKP VLEPLTPPLG SPRPRDARSF TPGRRNTAPS PGPSVIRRGR 420
RQSEPVKDPY VMFPQNAKPG FKHAGSEGEL YPPESQPPVS GSAPPEDLED AGPPTLDPSG 480
TSITEEILEL LNQRGLRDPG PSTHDIPKFP GDSQVPGDSE TLTFQALPSR DSSEEEEEEE 540
EGLEMDERGP SPLHVLEGLE SSIAAEMPSI PCLTKIPDVP NLPEIPSRCE IPEGSRLPSL 600
SDISDVFEMP CLPAIPSVPN TPSLSSTPTL SCDSWLQGPL QEPAEAPATR RELFSGSNPG 660
KLGEPPSGGK AGPEEDEEGV SFTDFQPQDV TQHQGFPDEL AFRSCSEIRS AWQALEQGQL 720
ARPGFPEPLL ILEDSDLGGD SGSGKAGAPS SERTASRVRE LARLYSERIQ QMQRAETRAS 780
ANAPRRRPRV LAQPQPSPCL PQEQAEPGLL PAFGHVLVCE LAFPLTCAQE SVPLGPAVWV 840
QAAIPLSKQG GSPDGQGLHV SNLPKQDLPG IHVSAATLLP EQGGSRHVQA PAATPLPKQE 900
GPLHLQVPAL TTFSDQGHPE IQVPATTPLP EHRSHMVIPA PSTAFCPEQG HCADIHVPTT 960
PALPKEICSD FTVSVTTPVP KQEGHLDSES PTNIPLTKQG GSRDVQGPDP VCSQPIQPLS 1020
WHGSSLDPQG PGDTLPPLPC HLPDLQIPGT SPLPAHGSHL DHRIPANAPL SLSQELPDTQ 1080
VPATTPLPLP QVLTDIWVQA LPTSPKQGSL PDIQGPAAAP PLPEPSLTDT QVQKLTPSLE 1140
QKSLIDAHVP AATPLPERGG SLDIQGLSPT PVQTTMVLSK PGGSLASHVA RNLWAFTGPR 1200
GLLMPPSTCE PGHEASLKQG FQPDAIDPQN LTWKSRH 1237 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS