CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024283
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cdc42 effector protein 1 
Protein Synonyms/Alias
 Binder of Rho GTPases 5 
Gene Name
 Cdc42ep1 
Gene Synonyms/Alias
 Borg5 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
30WVPSSHGKRRLTADMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity). 
Sequence Annotation
 DOMAIN 38 52 CRIB.
 REPEAT 237 243 1.
 REPEAT 250 256 2.
 REGION 237 270 2 X 7 AA tandem repeats of [PT]-[AT]-A-
 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 101 101 Phosphoserine (By similarity).
 MOD_RES 113 113 Phosphoserine (By similarity).
 MOD_RES 121 121 Phosphoserine (By similarity).
 MOD_RES 207 207 Phosphoserine (By similarity).
 MOD_RES 209 209 Phosphoserine (By similarity).
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 347 347 Phosphoserine (By similarity).
 MOD_RES 350 350 Phosphoserine (By similarity).  
Keyword
 Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MPGPQGGTGA PSMSLGKLSP VGWVPSSHGK RRLTADMISP PLGDFRHTMH VGRGGDVFGD 60
TSFLSNHGGR SGNTHRSPRS FLARKLQQVR RVGVPPRRMA SPAATSPAPP PISPIIKNAI 120
SLPQLNQATY DSLVVSKLSF DSTPASSTDG RSGYGLESGF CTISRLPRVE KHSSRDRDHD 180
RDPDHSQDRE QSSSPSEPNP NPELRRSDSL LSFRFDLDLG PSLLSELLGV MSLSEAPAAN 240
PPAPAANPAP TAKPPADAVT TLDTVTSLPA PTASSPSSGR FPNGVTAVLG PVAEVKASPV 300
GEGPQVPSKM AFDRRGASWG AIRASRHYTE MDARRELAGV LPQVHGSWES LNEEWSAPPA 360
SSRAPVPSTV QANAFEFADA DEDDEVKV 388 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara. 
Interpro
 IPR000095; PAK_box_Rho-bd. 
Pfam
 PF00786; PBD 
SMART
 SM00285; PBD 
PROSITE
 PS50108; CRIB 
PRINTS