CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulation of nuclear pre-mRNA domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 RPRD2 
Gene Synonyms/Alias
 KIAA0460; HSPC099 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
125KSVERIFKIWEDRNVubiquitination[1]
293KVVANAYKTFANRVNubiquitination[2, 3]
389KIIVEDRKEKPAEKSubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
 DOMAIN 19 149 CID.
 MOD_RES 356 356 Phosphoserine.
 MOD_RES 358 358 Phosphothreonine.
 MOD_RES 374 374 Phosphoserine.
 MOD_RES 473 473 Phosphoserine.
 MOD_RES 476 476 Phosphoserine.
 MOD_RES 479 479 Phosphoserine.
 MOD_RES 482 482 Phosphothreonine.
 MOD_RES 485 485 Phosphoserine.
 MOD_RES 517 517 Phosphothreonine.
 MOD_RES 593 593 Phosphoserine.
 MOD_RES 598 598 Phosphothreonine.
 MOD_RES 614 614 Phosphoserine.
 MOD_RES 665 665 Phosphoserine.
 MOD_RES 723 723 Phosphothreonine.
 MOD_RES 730 730 Phosphoserine (By similarity).
 MOD_RES 732 732 Phosphothreonine.
 MOD_RES 758 758 Phosphoserine.
 MOD_RES 762 762 Phosphoserine.
 MOD_RES 826 826 Phosphoserine.
 MOD_RES 900 900 Phosphoserine.
 MOD_RES 909 909 Phosphoserine.
 MOD_RES 928 928 Phosphoserine.
 MOD_RES 1021 1021 Phosphoserine (By similarity).
 MOD_RES 1099 1099 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1461 AA 
Protein Sequence
MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE NKKHHSTIVY 60
HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF ADVLPEAAAL VKDPSVSKSV 120
ERIFKIWEDR NVYPEEMIVA LREALSTTFK TQKQLKENLN KQPNKQWKKS QTSTNPKAAL 180
KSKIVAEFRS QALIEELLLY KRSEDQIELK EKQLSTMRVD VCSTETLKCL KDKTGGKKFS 240
KEFEEASSKL EEFVNGLDKQ VKNGPSLTEA LENAGIFYEA QYKEVKVVAN AYKTFANRVN 300
NLKKKLDQLK STLPDPEESP VPSPSMDAPS PTGSESPFQG MGGEESQSPT MESEKSATPE 360
PVTDNRDVED MELSDVEDDG SKIIVEDRKE KPAEKSAVST SVPTKPTENI SKASSCTPVP 420
VTMTATPPLP KPVNTSLSPS PALALPNLAN VDLAKISSIL SSLTSVMKNT GVSPASRPSP 480
GTPTSPSNLT SGLKTPAPAT TTSHNPLANI LSKVEITPES ILSALSKTQT QSAPALQGLS 540
SLLQSVTGNP VPASEAASQS TSASPANTTV STIKGRNLPS SAQPFIPKSF NYSPNSSTSE 600
VSSTSASKAS IGQSPGLPST TFKLPSNSLG FTATHNTSPA APPTEVTICQ SSEVSKPKLE 660
SESTSPSLEM KIHNFLKGNP GFSGLNLNIP ILSSLGSSAP SESHPSDFQR GPTSTSIDNI 720
DGTPVRDERS GTPTQDEMMD KPTSSSVDTM SLLSKIISPG SSTPSSTRSP PPGRDESYPR 780
ELSNSVSTYR PFGLGSESPY KQPSDGMERP SSLMDSSQEK FYPDTSFQED EDYRDFEYSG 840
PPPSAMMNLE KKPAKSILKS SKLSDTTEYQ PILSSYSHRA QEFGVKSAFP PSVRALLDSS 900
ENCDRLSSSP GLFGAFSVRG NEPGSDRSPS PSKNDSFFTP DSNHNSLSQS TTGHLSLPQK 960
QYPDSPHPVP HRSLFSPQNT LAAPTGHPPT SGVEKVLAST ISTTSTIEFK NMLKNASRKP 1020
SDDKHFGQAP SKGTPSDGVS LSNLTQPSLT ATDQQQQEEH YRIETRVSSS CLDLPDSTEE 1080
KGAPIETLGY HSASNRRMSG EPIQTVESIR VPGKGNRGHG REASRVGWFD LSTSGSSFDN 1140
GPSSASELAS LGGGGSGGLT GFKTAPYKER APQFQESVGS FRSNSFNSTF EHHLPPSPLE 1200
HGTPFQREPV GPSSAPPVPP KDHGGIFSRD APTHLPSVDL SNPFTKEAAL AHAAPPPPPG 1260
EHSGIPFPTP PPPPPPGEHS SSGGSGVPFS TPPPPPPPVD HSGVVPFPAP PLAEHGVAGA 1320
VAVFPKDHSS LLQGTLAEHF GVLPGPRDHG GPTQRDLNGP GLSRVRESLT LPSHSLEHLG 1380
PPHGGGGGGG SNSSSGPPLG PSHRDTISRS GIILRSPRPD FRPREPFLSR DPFHSLKRPR 1440
PPFARGPPFF APKRPFFPPR Y 1461 
Gene Ontology
 GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IDA:UniProtKB. 
Interpro
 IPR006569; CID_dom.
 IPR008942; ENTH_VHS.
 IPR006903; RNA_pol_II-bd. 
Pfam
 PF04818; CTD_bind 
SMART
 SM00582; RPR 
PROSITE
 PS51391; CID 
PRINTS