CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020414
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Niban 
Protein Synonyms/Alias
 Cell growth-inhibiting gene 39 protein; Protein FAM129A 
Gene Name
 FAM129A 
Gene Synonyms/Alias
 C1orf24; NIBAN; GIG39 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
105AVESYENKEAYQRGAubiquitination[1]
124RILPAGGKVLTSEDEubiquitination[1]
384SQNFQTTKDSVQLKEubiquitination[1]
482KVKLRVLKQYDYDSSubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). 
Sequence Annotation
 MOD_RES 579 579 Phosphoserine.
 MOD_RES 596 596 Phosphoserine.
 MOD_RES 602 602 Phosphoserine.
 MOD_RES 646 646 Phosphoserine.
 MOD_RES 926 926 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Stress response; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 928 AA 
Protein Sequence
MGGSASSQLD EGKCAYIRGK TEAAIKNFSP YYSRQYSVAF CNHVRTEVEQ QRDLTSQFLK 60
TKPPLAPGTI LYEAELSQFS EDIKKWKERY VVVKNDYAVE SYENKEAYQR GAAPKCRILP 120
AGGKVLTSED EYNLLSDRHF PDPLASSEKE NTQPFVVLPK EFPVYLWQPF FRHGYFCFHE 180
AADQKRFSAL LSDCVRHLNH DYMKQMTFEA QAFLEAVQFF RQEKGHYGSW EMITGDEIQI 240
LSNLVMEELL PTLQTDLLPK MKGKKNDRKR TWLGLLEEAY TLVQHQVSEG LSALKEECRA 300
LTKGLEGTIR SDMDQIVNSK NYLIGKIKAM VAQPAEKSCL ESVQPFLASI LEELMGPVSS 360
GFSEVRVLFE KEVNEVSQNF QTTKDSVQLK EHLDRLMNLP LHSVKMEPCY TKVNLLHERL 420
QDLKSRFRFP HIDLVVQRTQ NYMQELMENA VFTFEQLLSP HLQGEASKTA VAIEKVKLRV 480
LKQYDYDSST IRKKIFQEAL VQITLPTVQK ALASTCKPEL QKYEQFIFAD HTNMIHVENV 540
YEEILHQILL DETLKVIKEA AILKKHNLFE DNMALPSESV SSLTDLKPPT GSNQASPARR 600
ASAILPGVLG SETLSNEVFQ ESEEEKQPEV PSSLAKGESL SLPGPSPPPD GTEQVIISRV 660
DDPVVNPVAT EDTAGLPGTC SSELEFGGTL EDEEPAQEEP EPITASGSLK ALRKLLTASV 720
EVPVDSAPVM EEDTNGESHV PQENEEEEEK EPSQAAAIHP DNCEESEVSE REAQPPCPEA 780
HGEELGGFPE VGSPASPPAS GGLTEEPLGP MEGELPGEAC TLTAHEGRGG KCTEEGDASQ 840
QEGCTLGSDP ICLSESQVSE EQEEMGGQSS AAQATASVNA EEIKVARIHE CQWVVEDAPN 900
PDVLLSHKDD VKEGEGGQES FPELPSEE 928 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.
 GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
 GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
 GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB. 
Interpro
 IPR026088; Niban_like. 
Pfam
  
SMART
  
PROSITE
  
PRINTS