UniProt Accession

 SH21A_HUMAN; O60880; A8MSW0; O95383; O95384; O95385; O95386; Q6FGS6; Q9UNR0 

Genbank Protein ID

 AL023657; AF073019; AF072930; AB586694; AF100539; AF100540; AF100541; AF100542; AF100543; AK311911; CR542031; CR542043; AL022718; CH471107; CH471107; BC020732 

Genbank Nucleotide ID

 CAA19222.1; AAC62631.1; AAC62630.1; BAJ19023.1; AAC79712.1; AAC79713.1; AAC79714.1; AAC79715.1; AAC79716.1; BAG34852.1; CAG46828.1; CAG46840.1; CAA18777.1; EAX11848.1; EAX11849.1; AAH20732.1 

Protein Name

 SH2 domain-containing protein 1A 

Protein Synonyms/Alias

 Duncan disease SH2-protein; Signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; T-cell signal transduction molecule SAP 

Gene Name

 SH2D1A 

Gene Synonyms/Alias

 DSHP; SAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	AVAVYHGKISRETGE	ubiquitination	[1, 2]
18	ISRETGEKLLLATGL	ubiquitination	[1, 2]
74	ETAPGVHKRYFRKIK	ubiquitination	[1, 2]
89	NLISAFQKPDQGIVI	acetylation	[2, 3]
89	NLISAFQKPDQGIVI	ubiquitination	[1, 2]
104	PLQYPVEKKSSARST	ubiquitination	[1]
105	LQYPVEKKSSARSTQ	ubiquitination	[1]
126	EDPDVCLKAP*****	ubiquitination	[1, 2, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. 

Sequence Annotation

 DOMAIN 6 104 SH2.
 MOD_RES 89 89 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Polymorphism; Reference proteome; SH2 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005070; F:SH3/SH2 adaptor activity; NAS:UniProtKB.
 GO:0007267; P:cell-cell signaling; IDA:UniProtKB.
 GO:0006968; P:cellular defense response; NAS:UniProtKB.
 GO:0006959; P:humoral immune response; IEA:Compara.
 GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Compara. 

Interpro

 IPR000980; SH2.
 IPR017289; SH2_prot_1A. 

Pfam

 PF00017; SH2 

SMART

 SM00252; SH2 

PROSITE

 PS50001; SH2 

PRINTS

 PR00401; SH2DOMAIN.